Follicular Proinflammatory Cytokines and Chemokines as Markers of IVF Success
Table 3
Biomarkers in the follicular fluid of patient groups.
Male factor infertility ()a
Tubal factor infertility ()
Polycystic ovary syndrome ()
Endometriosis ()
Unexplained infertility ()
Other reasons ()
Total ()
Biomarkers (pg/mL)β
βG-CSF
82.5 (0β2464.0)
48.1 (0β4986.0)
104.1 (0β3156.0)
122.2 (0β4809.0)
118.5 (0β463.4)
23.7 (0β341.6)
89.7 (0β4986.0)
βIL-1Ξ²
0 (0β236.8)
0 (0β53.6)
0 (0β29.0)
0 (0β110.3)
0 (0-0)
0 (0β143.1)
0 (0β236.8)
βIL-6
0 (0β18.7)
0 (0β10.7)
0 (0β16.2)
0 (0β37.2)
0 (0-0)
0 (0β8.4)
0 (0β37.2)
βIL-12p70
0 (0β24.9)
0 (0β6.1)
0 (0β8.1)
0 (0β21.0)
0 (0-0)b
0 (0β8.1)
0 (0β24.9)
βIL-18
311.0 (0β722.0)
290.2 (0β812.5)
463.4 (0β648.5)
283.3 (44.6β874.3)
199.1 (0β255.5)b
310.9 (110.8β767.0)
297.2 (0β874.3)
βIL-23
282.3 (0β1069.0)
208.7 (0β1280.0)
237.4 (0β746.4)
388.8 (0β1160.0)
408.5 (0β557.8)
120.3 (0β260.3)
260.3 (0β1280.0)
βIFN-Ξ±
0 (0β150.7)
0 (0β107.6)
0 (0β93.5)
0 (0β114.2)
0 (0-0)
0 (0β161.9)
0 (0β161.9)
βIFN-Ξ³
0 (0β111.2)
0 (0β74.5)
0 (0β60.4)
0 (0β111.2)
0 (0-0)
9.5 (0β147.5)
9.5 (0β147.5)
βTNF-Ξ±
0 (0β30.7)
0 (0β10.8)
0 (0β5.3)
0 (0β21.0)
0 (0-0)
0 (0β58.8)
0 (0β58.8)
βIL-8
307.3 (119.4β4857.0)
367.2 (117.4β1117.0)b
417.6 (236.9β1032.0)
473.6 (172.8β 1879.0)b
424.3 (343.8β1472.0)
416.2 (172.8β2851.0)
371.2 (117.4β4857.0)
βMCP-1
1019.0 (594.2β2046.0)
1054.0 (416.1β2564.0)
1067.0 (656.4β1572.0)
1033.0 (373.8β2780.0)
992.9 (818.1β1265.0)
801.7 (198.4β1598.0)b
1016.0 (198.4β2780.0)
βMIP-1Ξ±
143.6 (0β5766.0)
80.6 (0β15990.0)
555.8 (0β19840.0)
227.6 (0β18230.0)
52.3 (0β3383.0)
136.3 (0β1788.0)
130.8 (0β19840.0)
βMIP-1Ξ²
52.3 (6.0β1254.0)
48.2 (11.5β433.2)
38.7 (17.59β96.4)
51.7 (17.1β120.9)
40.7 (36.8β64.5)
63.5 (25.7β967.0)
48.4 (6.0β1254.0)
βRANTES
97.4 (0β705.1)
97.4 (0β908.3)
50.1 (0β189.3)
146.6 (0β438.8)
77.4 (12.2β182.7)
74.1 (2.6β1428.0)
97.4 (0β1428.0)
βsAPO-1/Fas
129.0 (0β564.2)
169.4 (0β9589.0)
152.1 (0β4469.0)
94.9 (0β520.4)
96.8 (64.3β292.5)
98.8 (0β226.8)
129.0 (0β9589.0)
βCD44(var6)
8426.0 (5063.0β14030.0)
8554.0 (5348.0β20610.0)
10750.0 (6394.0β12130.0)b
8219.0 (5535.0β11770.0)
6619.0 (5168.0β9348.0)b
6836.0 (5611.0β10200.0)
8219.0 (5063.0β20610.0)
β Concentrations are provided as medians (minimum β maximum value). Differences between study groups: aReference group; bMann-Whitney -test, . Associations between different parameters assessed by adjusted regression models are provided in the text.