Table 1: Features of primary biliary cirrhosis (PBC) in men and women. Although PBC in men and women is largely similar, certain clinical features such as symptomatology and concomitant diseases differ between the sexes. Very little difference is noted in regards to histological or biochemical features, as well as antimitochondrial antibody (AMA) reactivity.


Age(i) Men older than women

Histopathology (i) Largely no difference observed
(ii) More stage I in women than in men in one study
(iii) One study notes more piecemeal necrosis and pseudoxanthomatous transformation in symptomatic females, and more stainable copper storage in symptomatic males

Symptomatology(i) Abdominal pain, constitutional symptoms, and pruritus as a single symptom more common in females
(ii) Jaundice as a single symptom more common in males

Biochemistry(i) Slightly increased ALP in males versus females in one study; higher -GT and ALT in men than in women in another

Concomitant autoimmune or other diseases(i) More females experienced Sicca symptoms, scleroderma, and Raynauds
(ii) Increased incidence of hepatoma in males

AMA reactivity(i) Similar antigenic reactivity patterns in males and females among studies

ANA reactivity (i) Anticentromere antibodies more prevalent in women than in men in one study