Polymerized-Type I Collagen Induces Upregulation of Foxp3-Expressing CD4 Regulatory T Cells and Downregulation of IL-17-Producing CD4 T Cells (Th17) Cells in Collagen-Induced Arthritis
Figure 1
Preventive and therapeutic effects of polymerized-type I collagen on mouse CIA. (a) Paw thickness in early arthritis model. One hundred microliters of Polymerized Collagen, 100 L of Polymerized Collagen, and 100 L of methotrexate (2.5 mg/kg) or 100 L of methotrexate (2.5 mg/kg)/Polymerized Collagen were administered intramuscular once a week during 6 weeks at the same time of that of the booster. Citric/citrate buffer was injected as a vehicle control. Data represent mean ± SEM (each group, ). (b) Clinical arthritis score in early arthritis model (). (c) Paw thickness in established arthritis model. One hundred microliters of Polymerized Collagen, 100 L of Polymerized Collagen, and 100 L of methotrexate (2.5 mg/kg) or 100 L of methotrexate (2.5 mg/kg)/Polymerized Collagen were administered intramuscularly once a week during 6 weeks. Treatments were started on 14 days after the booster. Citric/citrate buffer was injected as a vehicle control. Data represent mean ± SEM (each group, ). (d) Clinical arthritis score in established arthritis model (). *.
