Polymerized-Type I Collagen Induces Upregulation of Foxp3-Expressing CD4 Regulatory T Cells and Downregulation of IL-17-Producing CD4 T Cells (Th17) Cells in Collagen-Induced Arthritis
Figure 5
Effect of polymerized-type I collagen on the ex vivo NF-B and IB- in splenocytes. (a) Spleen cells obtained immediately ex vivo in early arthritis model on day 35 after booster immunization. (b) Splenocytes obtained immediately ex vivo in early arthritis model on day 98 after booster immunization. (c) Spleen cells obtained immediately ex vivo in established arthritis model during first sacrifice. (d) Splenocytes obtained from established arthritis model during second sacrifice. Intracellular levels of NF-Bp65 and IB cells were detected by flow cytometry. Results are representative of 6 mice analyzed in each group. Horizontal dotted line represent mean normal values, obtained from mice () without CIA. Data represent mean ± SEM. *.
