Journal of Immunology Research / 2012 / Article / Tab 2

Review Article

Indolent B-Cell Lymphomas Associated with HCV Infection: Clinical and Virological Features and Role of Antiviral Therapy

Table 2

Antiviral treatment in patients with indolent B-cell lymphoma associated with HCV infection.

YearN° ptsDiagnosisGenotypesCryoglobulinemiaAntiviral treatmentVirologic responseNHL response

Bauduer [63]19961MZL of MALT (oral cavity)NAα-IFN11 PR
Caramaschi et al. [64]19991MZL of MALT (salivary glands) NAα-IFNNA1 CR
Moccia et al. [65]19993SMZLNAα-IFNNA2 CR
Patriarca et al. [66]20011LPL2a/2cα-IFN11 CR
Hermine et al. [5]20029SLVLNA6α-IFN77 CR
Casato et al. [67]20021Leukemic MZLNA1α-IFNDecreased HCV-RNA1 CR
Pitini et al. [68]20042SMZLNAα-IFN22 CR
Tursi et al. [69]200416MZL of MALT (stomach) NAα-IFN-2b + RBV11/1616 CR
Kelaidi et al. [70]20048SMZL ( 𝑛 = 4 )
Disseminated
MZL ( 𝑛 = 1 )
Leukemic MZL ( 𝑛 = 1 )
MZL of MALT ( 𝑛 = 2 ) (1 duodenus; 1 ileus)
3a ( 𝑛 = 1 ), 5a ( 𝑛 = 1 )

1b
4c/4d
8α-IFN-2b + RBV5 SVR, 2 PR5 CR
Vallisa et al. [71]200513SMZL ( 𝑛 = 4 )
NMZL ( 𝑛 = 2 )
MZL of MALT ( 𝑛 = 2 )
FL ( 𝑛 = 1 )
LPL ( 𝑛 = 4 )
1b ( 𝑛 = 2 ), 2b ( 𝑛 = 1 )
2a/2c ( 𝑛 = 1 ), 1b ( 𝑛 = 1 )
1b ( 𝑛 = 2 )
2a
2a/2c ( 𝑛 = 1 ), 1n ( 𝑛 = 1 ),
na ( 𝑛 = 2 )
5Peg-IFN + RBV7 SVR, 1 PR7 CR, 2 PR
Svoboda et al. [72]20051MZL of MALT (salivary gland, liver) 2bPeg-IFN + RBV1CR
Saadoun et al. [17]200518SLVL1 ( 𝑛 = 7 )
2 ( 𝑛 = 4 )
3 ( 𝑛 = 1 )
4 ( 𝑛 = 1 )
18α-IFN (+ RBV in 10)14 CR, 4 PR14 CR, 4 PR
Paulli et al. [21]20092Subcutaneous MZL of MALT2a/2c
2b
2Peg-IFN + RBV2 CR1 CR, 1 PR
Oda et al. [73]20101B-NHL (liver) 2aPeg-IFN + RBVSVRCR
Mauro et al. [74]20121LPL1b1Peg-IFN + RBV (2nd line)SVRCR
Mazzaro et al. [75]2009181 SLVL
1 FL
16 LPL
1b ( 𝑛 = 1 1 )
2a/2c ( 𝑛 = 7 )
13α-IFN + RBV ( 𝑛 = 8 )
Peg-IFN + RBV ( 𝑛 = 1 0 )
9 SVR9 CR, 4 PR

SMZL: splenic marginal zone lymphoma; NMZL: nodal marginal zone lymphoma; SLVL: splenic lymphoma with villous lymphocytes; MZL: marginal zone lymphoma; FL: follicular lymphoma; LPL: lymphoplasmacytic lymphoma; MCL: mantle cell lymphoma; SLL: small lymphocytic lymphoma; NHL: non-Hodgkin’s lymphoma; NOS: not otherwise specified; IFN: interferon; RBV: ribavirin; CR: complete response; PR: partial response; SVR: sustained virologic response.

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