Journal of Immunology Research / 2012 / Article / Tab 1

Research Article

Macrophage Migration Inhibitory Factor in Fetoplacental Tissues from Preeclamptic Pregnancies with or without Fetal Growth Restriction

Table 1

Clinical characteristics of control and pathological pregnancies.

ControlsPE-AGAPE-FGR value a

Number of patients81010
Maternal age at delivery (years), mean (SD)32.8 (4.3)34.5 (3.8)32.5 (5.3)n.s.
Nulliparae, number and %7* (87.5)5* (50)8 (80) *0.041
Smoking mothers, number and %0° (0)2 (20)5° (50) °0.036
Prepregnancy BMI (Kg/m2), mean (SD)21.4 (2.5)24.2 (6.1)24.4 (4.7)n.s.
Gestational age at delivery (weeks), mean (SD)37.5*° (3.2)30.6* (2.6)30.0° (2.5) *°<0.001
Neonatal birth weight (g), mean (SD)3254*° (439) (309) (277) *°<0.001; 0.048
Neonatal weight Z-score, mean (SD)0.26*° (0.95) (0.30) (0.58) *0.018; °<0.001; 0.004
Placental weight (g), mean (SD)541° (81) (203) (58) °<0.001; 0.021
Placental weight/neonatal weight ratio, mean (SD)0.17* (0.01)0.31* (0.13)0.23 (0.10) *0.018
Gestational age at onset of PE (weeks), mean (SD)n.a.29.3 (3.1)28.5 (3.1)n.s.
Blood pressure (mmHg), mean (SD):
 Systolic110.9*° (9.4)158.4* (6.6)150.0° (18.9) *°<0.001
 Diastolic71.8*° (7.5)96.4* (9.5)93.9° (9.8) *°<0.001
Proteinuria, number and %:
 <1 g/24 h0 (0)0 (0)5 (50)
 <5 g/24 h0 (0)7 (70)3 (30) *°<0.001; 0.033
 ≥5 g/24 h0 (0)3 (30)2 (20)
Umbilical arterial mean pulsatility index, mean (SD)n.a.1.10 (0.17)2.03 (0.32) <0.001
Uterine arterial mean resistance index, mean (SD)n.a.0.67 (0.07)0.76 (0.05) 0.021
Patients receiving, number and %:
 Corticosteroids1*° (12.5)9* (90)10° (100) *<0.001; °0.003
 Antihypertensives0*° (0)10* (100)10° (100) *°<0.001
 Antibiotics2 (25.0)2 (20)0 (0)n.s.

PE: preeclampsia.
PE AGA: preeclamptic pregnancies with appropriate-for-gestational-age newborns.
PE-FGR: preeclamptic pregnancies with fetal growth restriction.
BMI: body mass index.
n.s.: not significant.
n.a.: not available.
a values were calculated by ANOVA test, followed by Tamhane test for pairwise comparison, or by chi-squared test ( ).
*Comparison between Controls and PE-AGA group.
°Comparison between Controls and PE-FGR group.
Comparison between PE-AGA and PE-FGR groups.

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