Review Article
T Cells in Gastric Cancer: Friends or Foes
Table 1
Th17 cells in cancer.
| Type of cancer | Organism | Role | Effect of subject | Reference |
| Pancreatic cancer | Mouse | Antitumor | Slower tumor growth and increased survival | Gnerlich et al. [101] | Melanoma | Mouse | Antitumor | Increase in activated CD8+ T cells and better antitumor efficacy | Sharma et al. [102] | Melanoma | Mouse | Antitumor | Th17-polarized cells were better at tumor eradication than Th1-polarized cells | Muranski et al. [103] | Ovarian cancer | Mouse | Pro-tumor | Lead to myeloid cell recruitment in the tumor environment and accelerated tumor growth | Charles et al. [90] | Hepatocellular carcinoma | Mouse | Pro-tumor | Decrease of intratumoral Th17 was associated with decreased tumor growth | Kuang et al. [91] | Prostate cancer | Human | Pro-tumor | Higher pretreatment Th17 numbers correlated with faster disease progression | Derhovanessian et al. [99] | Ovarian cancer | Human | Antitumor | Th17 levels correlated positively with patients survival | Kryczek et al. [82] | Prostate cancer | Human | Antitumor | More highly differentiated Th17 in prostate correlated with slower disease progression | Sfanos et al. [85] | Lung adenocarcinoma | Human | Antitumor | Th17 accumulation correlated positively with patient survival | Ye et al. [104] |
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