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Clinical and Developmental Immunology
Volume 2012, Article ID 734865, 10 pages
http://dx.doi.org/10.1155/2012/734865
Clinical Study

Intrauterine Growth Restriction: Cytokine Profiles of Trophoblast Antigen-Stimulated Maternal Lymphocytes

1Department of Microbiology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Kuwait 13110, Kuwait
2Department of Obstetrics & Gynecology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Kuwait 13110, Kuwait
3Department of Mathematics & Biology, Gulf University for Science and Technology, Mubarak Al-Abdullah Area, West Mishref, Hawalli 32093, Kuwait

Received 28 June 2011; Revised 16 August 2011; Accepted 16 August 2011

Academic Editor: Andres Salumets

Copyright © 2012 Raj Raghupathy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Bulletins ACoP, “Intrauterine growth restriction,” ACOG Practice Bulletin, vol. 12, pp. 1–3, 2000. View at Google Scholar
  2. I. M. Bernstein, J. D. Horbar, G. J. Badger, A. Ohlsson, and A. Golan, “Morbidity and mortality among very-low-birth-weight neonates with intrauterine growth restriction,” American Journal of Obstetrics and Gynecology, vol. 182, no. 1, pp. 198–206, 2000. View at Google Scholar · View at Scopus
  3. V. E. Murphy, R. Smith, W. B. Giles, and V. L. Clifton, “Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus,” Endocrine Reviews, vol. 27, no. 2, pp. 141–169, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Brodsky and H. Christou, “Current concepts in intrauterine growth restriction,” Journal of Intensive Care Medicine, vol. 19, no. 6, pp. 307–319, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. D. J. Roberts and M. D. Post, “The placenta in pre-eclampsia and intrauterine growth restriction,” Journal of Clinical Pathology, vol. 61, no. 12, pp. 1254–1260, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Resnik and R. Creasy, “Intrauterine growth restriction,” in Maternal Fetal Medicine: Principles and Practice, R. D. Creasy and R. Resnik, Eds., pp. 495–512, Saunders, Philadelphia, Pa, USA, 2004. View at Google Scholar
  7. R. E. Reiss, “Intrauterine growth restriction,” in The Physiologic Basis of Gynecology and Obstetrics, D. B. Seifet, P. Samuels, and D. A. Kniss, Eds., pp. 513–530, Lippincott Williams and Wilkins, 2001. View at Google Scholar
  8. H. Fox, “Placental pathology,” in Intrauterine Growth Restriction: Aetiology and Management, J. Kingdom and P. Barer, Eds., pp. 991–998, Springer, London, UK, 2000. View at Google Scholar
  9. T. G. Wegmann, H. Lin, L. Guilbert, and T. R. Mosmann, “Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?” Immunology Today, vol. 14, no. 7, pp. 353–356, 1993. View at Google Scholar · View at Scopus
  10. R. Raghupathy, “Pregnancy: success and failure within the Th1/Th2/Th3 paradigm,” Seminars in Immunology, vol. 13, no. 4, pp. 219–227, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. J. A. Hill and B. C. Choi, “Immunodystrophism: evidence for a novel alloimmune hypothesis for recurrent pregnancy loss involving Th1-type immunity to trophoblast,” Seminars in Reproductive Medicine, vol. 18, no. 4, pp. 401–406, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. M. P. Piccinni, “T cells in normal pregnancy and recurrent pregnancy loss,” Reproductive BioMedicine Online, vol. 13, no. 6, pp. 840–844, 2006. View at Google Scholar · View at Scopus
  13. R. Raghupathy, M. Makhseed, R. Azizieh, A. Omu, M. Gupta, and R. Farhat, “Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion,” Human Reproduction, vol. 15, no. 3, pp. 713–718, 2000. View at Google Scholar · View at Scopus
  14. J. A. Keelan, K. W. Marvin, T. A. Sato, M. Coleman, L. M. E. McCowan, and M. D. Mitchell, “Cytokine abundance in placental tissues: evidence of inflammatory activation in gestational membranes with term and preterm parturition,” American Journal of Obstetrics and Gynecology, vol. 181, no. 6, pp. 1530–1536, 1999. View at Google Scholar · View at Scopus
  15. R. Romero, O. Erez, and J. Espinoza, “Intrauterine infection, preterm labor, and cytokines,” Journal of the Society for Gynecologic Investigation, vol. 12, no. 7, pp. 463–465, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Saito, A. Shiozaki, A. Nakashima, M. Sakai, and Y. Sasaki, “The role of the immune system in preeclampsia,” Molecular Aspects of Medicine, vol. 28, no. 2, pp. 192–209, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. F. Azizieh, R. Raghupathy, and M. Makhseed, “Maternal cytokine production patterns in women with pre-eclampsia,” American Journal of Reproductive Immunology, vol. 54, no. 1, pp. 30–37, 2005. View at Google Scholar · View at Scopus
  18. S. Romagnani, “Human TH1 and TH2 subsets: regulation of differentiation and role in protection and immunopathology,” International Archives of Allergy and Immunology, vol. 98, no. 4, pp. 279–285, 1992. View at Google Scholar · View at Scopus
  19. T. R. Mosmann and S. Sad, “The expanding universe of T-cell subsets: Th1, Th2 and more,” Immunology Today, vol. 17, no. 3, pp. 138–146, 1996. View at Publisher · View at Google Scholar · View at Scopus
  20. J. A. Hill, K. Polgar, and D. J. Anderson, “T-helper 1-type immunity to trophoblast in women with recurrent spontaneous abortion,” Journal of the American Medical Association, vol. 273, no. 24, pp. 1933–1936, 1995. View at Google Scholar · View at Scopus
  21. R. Raghupathy, M. Makhseed, F. Azizieh, N. Hassan, M. Al-Azemi, and E. Al-Shamali, “Maternal Th1- and Th2-type reactivity to placental antigens in normal human pregnancy and unexplained recurrent spontaneous abortions,” Cellular Immunology, vol. 196, no. 2, pp. 122–130, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. K. Polgar and J. A. Hill, “Identification of the white blood cell populations responsible for Th1 immunity to trophoblast and the timing of the response in women with recurrent pregnancy loss,” Gynecologic and Obstetric Investigation, vol. 53, no. 1, pp. 59–64, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Faul, E. Erdfelder, A. G. Lang, and A. Buchner, “G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences,” Behavior Research Methods, vol. 39, no. 2, pp. 175–191, 2007. View at Google Scholar · View at Scopus
  24. P. Zimmermann, V. Eiriö, J. Koskinen, E. Kujansuu, and T. Ranta, “Doppler assessment of the uterine and uteroplacental circulation in the second trimester in pregnancies at high risk for pre-eclampsia and/or intrauterine growth retardation: comparison and correlation between different Doppler parameters,” Ultrasound in Obstetrics and Gynecology, vol. 9, no. 5, pp. 330–338, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. D. G. Remick, “Interleukin-8,” Critical Care Medicine, vol. 33, no. 12, pp. S466–S467, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. J. V. Stein and C. Nombela-Arrieta, “Chemokine control of lymphocyte trafficking: a general overview,” Immunology, vol. 116, no. 1, pp. 1–12, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Tosun, H. Celik, B. Avci, E. Yavuz, T. Alper, and E. Malatyalioǧlu, “Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-α in normal pregnancies and in pregnancies complicated by preeclampsia,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 23, no. 8, pp. 880–886, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Laskowska, K. Laskowska, B. Leszczynska-Gorzelak, and J. Oleszczuk, “Comparative analysis of the maternal and umbilical interleukin-8 levels in normal pregnancies and in pregnancies complicated by preeclampsia with intrauterine normal growth and intrauterine growth retardation,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 20, no. 7, pp. 527–532, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. M. R. Johnson, N. Anim-Nyame, P. Johnson, S. R. Sooranna, and P. J. Steer, “Does endothelial cell activation occur with intrauterine growth restriction?” British Journal of Obstetrics and Gynecology, vol. 109, no. 7, pp. 836–839, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Hahn-Zoric, H. Hagberg, I. Kjellmer, J. Ellis, M. Wennergren, and L. Å. Hanson, “Aberrations in placental cytokine mRNA related to intrauterine growth retardation,” Pediatric Research, vol. 51, no. 2, pp. 201–206, 2002. View at Google Scholar · View at Scopus
  31. M. Li and S. J. Huang, “Innate immunity, coagulation and placenta-related adverse pregnancy outcomes,” Thrombosis Research, vol. 124, no. 6, pp. 656–662, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Pestka, C. D. Krause, and M. R. Walter, “Interferons, interferon-like cytokines, and their receptors,” Immunological Reviews, vol. 202, pp. 8–32, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. T. Hehlgans and K. Pfeffer, “The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games,” Immunology, vol. 115, no. 1, pp. 1–20, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. G. I. Neta, O. S. Von Ehrenstein, L. R. Goldman et al., “Umbilical cord serum cytokine levels and risks of small-for-gestational-age and preterm birth,” American Journal of Epidemiology, vol. 171, no. 8, pp. 859–867, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Laskowska, B. Leszczyńska-Gorzelak, K. Laskowska, and J. Oleszczuk, “Evaluation of maternal and umbilical serum TNFα levels in preeclamptic pregnancies in the intrauterine normal and growth-restricted fetus,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 19, no. 6, pp. 347–351, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. G. Amarilyo, A. Oren, F. B. Mimouni, Y. Ochshorn, V. Deutsch, and D. Mandel, “Increased cord serum inflammatory markers in small-for-gestational-age neonates,” Journal of Perinatology, vol. 31, no. 1, pp. 30–32, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. G. Holcberg, M. Huleihel, O. Sapir et al., “Increased production of tumor necrosis factor-α TNF-α by IUGR human placentae,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 94, no. 1, pp. 69–72, 2001. View at Publisher · View at Google Scholar · View at Scopus
  38. S. J. Rogerson, H. C. Brown, E. Pollina et al., “Placental tumor necrosis factor alpha but not gamma interferon is associated with placental malaria and low birth weight in Malawian women,” Infection and Immunity, vol. 71, no. 1, pp. 267–270, 2003. View at Publisher · View at Google Scholar · View at Scopus
  39. K. P. Conrad and D. F. Bfnyo, “Placental cytokines and the pathogenesis of preeclampsia,” American Journal of Reproductive Immunology, vol. 37, no. 3, pp. 240–249, 1997. View at Google Scholar · View at Scopus
  40. N. Carbo, F. J. Lopez-Soriano, and J. M. Argiles, “Administration of tumor necrosis factor-α results in a decreased placental transfer of amino acids in the rat,” Endocrinology, vol. 136, no. 8, pp. 3579–3584, 1995. View at Google Scholar · View at Scopus
  41. J. S. Hunt, R. A. Atherton, and J. L. Pace, “Differential responses of rat trophoblast cells and embryonic fibroblasts to cytokines that regulate proliferation and class I MHC antigen expression,” Journal of Immunology, vol. 145, no. 1, pp. 184–189, 1990. View at Google Scholar · View at Scopus
  42. P. P. Nawroth and D. M. Stern, “Modulation of endothelial cell hemostatic properties by tumor necrosis factor,” Journal of Experimental Medicine, vol. 163, no. 3, pp. 740–745, 1986. View at Google Scholar · View at Scopus
  43. M. P. Bevilacqua, J. S. Pober, G. R. Majeau, W. Fiers, R. S. Cotran, and M. A. Gimbrone Jr., “Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1,” Proceedings of the National Academy of Sciences of the United States of America, vol. 83, no. 12, pp. 4533–4536, 1986. View at Google Scholar
  44. C. M. Scifres and D. M. Nelson, “Intrauterine growth restriction, human placental development and trophoblast cell death,” Journal of Physiology, vol. 587, no. 14, pp. 3453–3458, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. J. Yui, M. Garcia-Lloret, T. G. Wegmann, and L. J. Guilbert, “Cytotoxicity of tumour necrosis factor-alpha and gamma-interferon against primary human placental trophoblasts,” Placenta, vol. 15, no. 8, pp. 819–835, 1994. View at Publisher · View at Google Scholar · View at Scopus
  46. R. T. Kilani, M. Mackova, S. T. Davidge, B. Winkler-Lowen, N. Demianczuk, and L. J. Guilbert, “Endogenous tumor necrosis factor α mediates enhanced apoptosis of cultured villous trophoblasts from intrauterine growth-restricted placentae,” Reproduction, vol. 133, no. 1, pp. 257–264, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. N. Ishihara, H. Matsuo, H. Murakoshi, J. B. Laoag-Fernandez, T. Samoto, and T. Maruo, “Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation,” American Journal of Obstetrics and Gynecology, vol. 186, no. 1, pp. 158–166, 2002. View at Publisher · View at Google Scholar · View at Scopus
  48. S. Yano, S. Sone, Y. Nishioka, N. Mukaida, K. Matsushima, and T. Ogura, “Differential effects of anti-inflammatory cytokines (IL-4, IL-10 and IL-13) on tumoricidal and chemotactic properties of human monocytes induced by monocyte chemotactic and activating factor,” Journal of Leukocyte Biology, vol. 57, no. 2, pp. 303–309, 1995. View at Google Scholar · View at Scopus
  49. G. B. Dealtry, M. K. O'Farrell, and N. Fernandez, “The Th2 cytokine environment of the placenta,” International Archives of Allergy and Immunology, vol. 123, no. 2, pp. 107–119, 2000. View at Google Scholar · View at Scopus
  50. A. M. Borzychowski, I. L. Sargent, and C. W. G. Redman, “Inflammation and pre-eclampsia,” Seminars in Fetal and Neonatal Medicine, vol. 11, no. 5, pp. 309–316, 2006. View at Publisher · View at Google Scholar · View at Scopus
  51. A. O'Garra, F. J. Barrat, A. G. Castro, A. Vicari, and C. Hawrylowicz, “Strategies for use of IL-10 or its antagonists in human disease,” Immunological Reviews, vol. 223, no. 1, pp. 114–131, 2008. View at Publisher · View at Google Scholar · View at Scopus
  52. K. W. Moore, R. De Waal Malefyt, R. L. Coffman, and A. O'Garra, “Interleukin-10 and the interleukin-10 receptor,” Annual Review of Immunology, vol. 19, pp. 683–765, 2001. View at Publisher · View at Google Scholar · View at Scopus
  53. C. A. Murphy, C. L. Langrish, Y. Chen et al., “Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation,” Journal of Experimental Medicine, vol. 198, no. 12, pp. 1951–1957, 2003. View at Publisher · View at Google Scholar · View at Scopus
  54. A. E. Mas, M. Petitbarat, S. Dubanchet, S. Fay, N. Ledée, and G. Chaouat, “Immune regulation at the interface during early steps of murine implantation: involvement of two new cytokines of the IL-12 family (IL-23 and IL-27) and of TWEAK,” American Journal of Reproductive Immunology, vol. 59, no. 4, pp. 323–338, 2008. View at Publisher · View at Google Scholar · View at Scopus
  55. S. Vujisić, S. Ž. Lepej, I. Emedi, R. Bauman, A. Remenar, and M. K. Tiljak, “Ovarian follicular concentration of IL-12, IL-15, IL-18 and p40 subunit of IL-12 and IL-23,” Human Reproduction, vol. 21, no. 10, pp. 2650–2655, 2006. View at Publisher · View at Google Scholar · View at Scopus
  56. D. Lin, M. A. Smith, J. Elter et al., “Porphyromonas gingivalis infection in pregnant mice is associated with placental dissemination, an increase in the placental Th1/Th2 cytokine ratio, and fetal growth restriction,” Infection and Immunity, vol. 71, no. 9, pp. 5163–5168, 2003. View at Publisher · View at Google Scholar · View at Scopus