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Clinical and Developmental Immunology
Volume 2012, Article ID 738043, 8 pages
http://dx.doi.org/10.1155/2012/738043
Research Article

Identification of RD5-Encoded Mycobacterium tuberculosis Proteins As B-Cell Antigens Used for Serodiagnosis of Tuberculosis

Miao-Miao Zhang,1,2 Jun-Wei Zhao,1 Zhan-Qiang Sun,3 Jun Liu,4 Xiao-Kui Guo,1 Wen-Di Liu,2,5 and Shu-Lin Zhang1,5

1Department of Microbiology and Parasitology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
2Department of Immunology, Xinxiang Medical University, Xinxiang 453000, China
3Shanghai Kaidi Biotech Co., Ltd., Shanghai 200433, China
4Wuxi No. 5 People’s Hospital, Wuxi 214005, China
5Department of Biochemistry, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China

Received 31 December 2011; Accepted 1 April 2012

Academic Editor: Mario Clerici

Copyright © 2012 Miao-Miao Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. WHO, “Global tuberculosis control,” WHO Report, 2011. View at Google Scholar
  2. E. Stokstad, “Infectious disease—drug-resistant TB on the rise,” Science, vol. 287, no. 5462, p. 2391, 2000. View at Google Scholar · View at Scopus
  3. R. Koenig, “Drug-resistant tuberculosis—in South Africa, XDR TB and HIV prove a deadly combination,” Science, vol. 319, no. 5865, pp. 894–897, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. D. L. Kasper, E. Braunwald, A. S. Fauci et al., Harrison's Principles of Internal Medicine, McGraw-Hill Companies, New York, NY, USA, 16th edition, 2005.
  5. Z. Y. Zhang, Z. Q. Sun, Z. L. Wang et al., “Complete genome sequence of a novel clinical isolate, the Nontuberculous mycobacterium strain JDM601,” Journal of Bacteriology, vol. 193, no. 16, pp. 4300–4301, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. J. S. Bergmann, W. E. Keating, and G. L. Woods, “Clinical evaluation of the BDProbeTec ET System for rapid detection of Mycobacterium tuberculosis,” Journal of Clinical Microbiology, vol. 38, no. 2, pp. 863–865, 2000. View at Google Scholar · View at Scopus
  7. G. Mazzarelli, L. Rindi, P. Piccoli, C. Scarparo, C. Garzelli, and E. Tortoli, “Evaluation of the BDProbeTec ET system for direct detection of Mycobacterium tuberculosis in pulmonary and extrapulmonary samples: a multicenter study,” Journal of Clinical Microbiology, vol. 41, no. 4, pp. 1779–1782, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Sester, G. Sotgiu, C. Lange et al., “Interferon-γ release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis,” European Respiratory Journal, vol. 37, no. 1, pp. 100–111, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. C. B. E. Chee, T. M. S. Barkham, K. W. KhinMar, S. H. Gan, and Y. T. Wang, “Quantitative T-cell interferon-gamma responses to Mycobacterium tuberculosis-specific antigens in active and latent tuberculosis,” European Journal of Clinical Microbiology and Infectious Diseases, vol. 28, no. 6, pp. 667–670, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. J. P. Janssens, P. Roux-Lombard, T. Perneger, M. Metzger, R. Vivien, and T. Rochat, “Quantitative scoring of an interferon-γ assay for differentiating active from latent tuberculosis,” European Respiratory Journal, vol. 30, no. 4, pp. 722–727, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Aloring, “Agglutination du bacilli de la tuberculose vraie,” Comptes Rendus de l'Académie des Sciences, vol. 126, pp. 1398–1400, 1898. View at Google Scholar
  12. H. Zhang, J. Wang, J. Lei et al., “PPE protein (Rv3425) from DNA segment RD11 of Mycobacterium tuberculosis: a potential B-cell antigen used for serological diagnosis to distinguish vaccinated controls from tuberculosis patients,” Clinical Microbiology and Infection, vol. 13, no. 2, pp. 139–145, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Khan, K. Alam, S. Nair, V. L. Valluri, K. J. R. Murthy, and S. Mukhopadhyay, “Association of strong immune responses to PPE protein Rv1168c with active tuberculosis,” Clinical and Vaccine Immunology, vol. 15, no. 6, pp. 974–980, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. I. Rosenkrands, C. Aagaard, K. Weldingh et al., “Identification of Rv0222 from RD4 as a novel serodiagnostic target for tuberculosis,” Tuberculosis, vol. 88, no. 4, pp. 335–343, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. R. K. Choudhary, S. Mukhopadhyay, P. Chakhaiyar et al., “PPE antigen Rv2430c of Mycobacterium tuberculosis induces a strong B-cell response,” Infection and Immunity, vol. 71, no. 11, pp. 6338–6343, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. P. S. Jackett, G. H. Bothamley, H. V. Batra, A. Mistry, D. B. Young, and J. Ivanyi, “Specificity of antibodies to immunodominant mycobacterial antigens in pulmonary tuberculosis,” Journal of Clinical Microbiology, vol. 26, no. 11, pp. 2313–2318, 1988. View at Google Scholar · View at Scopus
  17. B. Brust, M. Lecoufle, E. Tuaillon et al., “Mycobacterium tuberculosis lipolytic enzymes as potential biomarkers for the diagnosis of active tuberculosis,” PLoS ONE, vol. 6, no. 9, Article ID e25078, 2011. View at Google Scholar
  18. J.-W. Zhao, Z.-Q. Sun, H.-G. Yang et al., “Cloning, expression and immunological evaluation of a short fragment from Rv3391 of Mycobacterium tuberculosis,” Annals of Microbiology, vol. 61, no. 2, pp. 345–353, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. G. G. Mahairas, P. J. Sabo, M. J. Hickey, D. C. Singh, and C. K. Stover, “Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis,” Journal of Bacteriology, vol. 178, no. 5, pp. 1274–1282, 1996. View at Google Scholar · View at Scopus
  20. M. A. Behr, M. A. Wilson, W. P. Gill et al., “Comparative genomics of BCG vaccines by whole-genome DNA microarray,” Science, vol. 284, no. 5419, pp. 1520–1523, 1999. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Mukherjee, M. Dutta, P. Datta et al., “The RD1-encoded antigen Rv3872 of Mycobacterium tuberculosis as a potential candidate for serodiagnosis of tuberculosis,” Clinical Microbiology and Infection, vol. 13, no. 2, pp. 146–152, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. P. N. Brusasca, R. Colangeli, K. P. Lyashchenko et al., “Immunological characterization of antigens encoded by the RD1 region of the Mycobacterium tuberculosis genome,” Scandinavian Journal of Immunology, vol. 54, no. 5, pp. 448–452, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. S. L. Zhang, J. W. Zhao, Z. Q. Sun et al., “Development and evaluation of a novel multiple-antigen ELISA for serodiagnosis of tuberculosis,” Tuberculosis, vol. 89, no. 4, pp. 278–284, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Davidow, G. V. Kanaujia, L. Shi et al., “Antibody profiles characteristic of Mycobacterium tuberculosis infection state,” Infection and Immunity, vol. 73, no. 10, pp. 6846–6851, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. S. L. Zhang, J. W. Zhao, Z. Q. Sun et al., “Development and evaluation of a novel multiple-antigen ELISA for serodiagnosis of tuberculosis,” Tuberculosis, vol. 89, no. 4, pp. 278–284, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. J. W. Zhao, Z. Q. Sun, H. G. Yang et al., “Cloning, expression and immunological evaluation of a short fragment from Rv3391 of Mycobacterium tuberculosis,” Annals of Microbiology, vol. 61, no. 2, pp. 345–353, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. Z. Cheng, J. W. Zhao, Z. Q. Sun et al., “Evaluation of a novel fusion protein antigen for rapid serodiagnosis of tuberculosis,” Journal of Clinical Laboratory Analysis, vol. 25, no. 5, pp. 344–349, 2011. View at Google Scholar
  28. O. Parkash, B. P. Singh, and M. Pai, “Regions of differences encoded antigens as targets for immunodiagnosis of tuberculosis in humans,” Scandinavian Journal of Immunology, vol. 70, no. 4, pp. 345–357, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Lyashchenko, R. Colangeli, M. Houde, H. Al Jahdali, D. Menzies, and M. L. Gennaro, “Heterogeneous antibody responses in tuberculosis,” Infection and Immunity, vol. 66, no. 8, pp. 3936–3940, 1998. View at Google Scholar · View at Scopus
  30. H. Song, R. Sandie, Y. Wang, M. A. Andrade-Navarro, and M. Niederweis, “Identification of outer membrane proteins of Mycobacterium tuberculosis,” Tuberculosis, vol. 88, no. 6, pp. 526–544, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Krawczyk, T. A. Kohl, A. Goesmann, J. Kalinowski, and J. Baumbach, “From Corynebacterium glutamicum to Mycobacterium tuberculosis—towards transfers of gene regulatory networks and integrated data analyses with MycoRegNet,” Nucleic Acids Research, vol. 37, no. 14, article e97, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. L. M. Wolfe, S. B. Mahaffey, N. A. Kruh, and K. M. Dobos, “Proteomic definition of the cell wall of Mycobacterium tuberculosis,” Journal of Proteome Research, vol. 9, no. 11, pp. 5816–5826, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. K. R. Rao, F. Kauser, S. Srinivas et al., “Analysis of genomic downsizing on the basis of region-of-difference polymorphism profiling of Mycobacterium tuberculosis patient isolates reveals geographic partitioning,” Journal of Clinical Microbiology, vol. 43, no. 12, pp. 5978–5982, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Lyashchenko, R. Colangeli, M. Houde, H. Al Jahdali, D. Menzies, and M. L. Gennaro, “Heterogeneous antibody responses in tuberculosis,” Infection and Immunity, vol. 66, no. 8, pp. 3936–3940, 1998. View at Google Scholar · View at Scopus
  35. S. Kunnath-Velayudhan, H. Salamon, H. Y. Wang et al., “Dynamic antibody responses to the Mycobacterium tuberculosis proteome,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 33, pp. 14703–14708, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. M. J. Sartain, R. A. Slayden, K. K. Singh, S. Laal, and J. T. Belisle, “Disease state differentiation and identification of tuberculosis biomarkers via native antigen array profiling,” Molecular and Cellular Proteomics, vol. 5, no. 11, pp. 2102–2113, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. N. Y. Al-Khodari, R. Al-Attiyah, and A. S. Mustafa, “Identification, diagnostic potential, and natural expression of immunodominant seroreactive peptides encoded by five Mycobacterium tuberculosis-specific genomic regions,” Clinical and Vaccine Immunology, vol. 18, no. 3, pp. 477–482, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. A. S. Mustafa and R. Al-Attiyah, “Identification of Mycobacterium tuberculosis-specific genomic regions encoding antigens inducing protective cellular immune responses,” Indian Journal of Experimental Biology, vol. 47, no. 6, pp. 498–504, 2009. View at Google Scholar · View at Scopus