Journal of Immunology Research / 2012 / Article / Tab 2

Research Article

Toll-Like Receptor Transcriptome in the HPV-Positive Cervical Cancer Microenvironment

Table 2

Summary of literature of dysregulated innate immunity genes in cervical tissue. A systematic literature search for investigations into TLR and IFN expression in HPV-infected cervical tissue or cell lines was performed using the following search terms in the PubMed database: “Cervical” and “interferon gamma” (489 hits) or “interferon beta” (202 hits) or “interferon kappa” (3 hits) or “toll-like receptor” (59 hits). Acronyms IFN-γ, -β and -κ as well as TLR in combination with “cervical” were also tried. The listed citations are articles published up to 5 January 2011 which describe TLR and IFN gene regulation and dysregulation. Only articles published in English were considered, and only articles relevant for our study were included in the table.

GeneMaterialSample typeMethodGroup
NormalCINCarcinoma

151113Full biopsyqPCRPao et al. 1995 [28]
412N/SFull biopsy, HeLaqPCR, IHCde Gruijl et al. 1999 [29]
N/AN/A52Full biopsyqPCR, IHCGey et al. 2003 [30]
IFN-γ10N/A29Full biopsyqPCR, IHCAlcocer-González et al. 2006 [31]
6N/A6CytobrushcDNA arrayManavi et al. 2007 [31]
150198N/AFull biopsyqPCRScott et al. 2009 [32]
N/SN/SN/SFull biopsy, LCMqPCRDeCarlo et al. 2008 [27]
11104Full biopsy, LCMqPCRDeCarlo et al. 2010 [19]

N/AN/AN/ACKcDNA array, qPCRNees et al. 2001 [33]
IFN-βN/SN/SN/SFull biopsy, LCMqPCRDeCarlo et al. 2008 [27]
11104Full biopsy, LCMqPCRDeCarlo et al. 2010 [19]

N/SN/SN/SFull biopsy, LCMqPCRDeCarlo et al. 2008 [27]
IFN-κN/S10N/AFull biopsy, PHFKqPCR, IHCRincon-Orozco et al. 2009 [34]
11104Full biopsy, LCMqPCRDeCarlo et al. 2010 [19]

34N/ACK, PHK, SiHa, CaSki, HeLa, C33AqPCRHasan et al. 2007 [25]
TLR112N/AN/ACK, VK, ME180, HeLaqPCRHerbst-Kralovetz et al. 2008 [35]
6565N/ACytobrushqPCRDaud et al. 2010 [24]

34N/ACK, PHK, SiHa, CaSki, HeLa, C33AqPCRHasan et al. 2007 [26]
TLR212N/AN/ACK, VK, ME180, HeLaqPCRHerbst-Kralovetz et al. 2008 [35]
6565N/ACytobrushqPCRDaud et al. 2010 [24]

34N/ACK, PHK, SiHa, CaSki, HeLa, C33AqPCR, IFHasan et al. 2007 [26]
TLR312N/AN/ACK, VK, ME180, HeLaqPCRHerbst-Kralovetz et al. 2008 [35]
6565N/ACytobrushqPCRDaud et al. 2010 [24]

34N/ACK, PHK, SiHa, CaSki, HeLa, C33AqPCRHasan et al. 2007 [26]
TLR412N/AN/ACK, VK, ME180, HeLaqPCRHerbst-Kralovetz et al. 2008 [35]
2012549Full biopsyqPCR, IHCYu et al. 2010 [25]

34N/ACK, PHK, SiHa, CaSki, HeLa, C33AqPCRHasan et al. 2007 [19]
TLR512N/AN/ACK, VK, ME180, HeLaqPCRHerbst-Kralovetz et al. 2008 [35]
92224Full biopsyqPCRKim et al. 2008 [36]

34N/ACK, PHK, SiHa, CaSki, HeLa, C33AqPCRHasan et al. 2007 [26]
TLR612N/AN/ACK, VK, ME180, HeLaqPCRHerbst-Kralovetz et al. 2008 [35]
6565N/ACytobrushqPCRDaud et al. 2010 [24]

34N/ACK, PHK, SiHa, CaSki, HeLa, C33AqPCRHasan et al. 2007 [26]
TLR712N/AN/ACK, VK, ME180, HeLaqPCRHerbst-Kralovetz et al. 2008 [35]
6565N/ACytobrushqPCRDaud et al. 2010 [24]

34N/ACK, PHK, SiHa, CaSki, HeLa, C33AqPCRHasan et al. 2007 [19]
TLR812N/AN/ACK, VK, ME180, HeLaqPCRHerbst-Kralovetz et al. 2008 [35]
6565N/ACytobrushqPCRDaud et al. 2010 [24]

34N/AFull biopsy, CK, PHK, SiHa, CaSki, HeLa, C33AqPCR, IF, IHCHasan et al. 2007 [26]
92224Full biopsyqPCRLee et al. 2007 [37]
TLR912N/AN/ACK, VK, ME180, HeLaqPCRHerbst-Kralovetz et al. 2008 [35]
6565N/ACytobrushqPCRDaud et al. 2010 [24]
2012549Full biopsyqPCR, IHCYu et al. 2010 [25]

CIN, cervical intraepithelial neoplasia; CK, in vitro cervical keratinocytes; IF, immunofluorescence; IHC, immunohistochemistry; LCM, laser capture microdissection; N/A, not applicable; N/S, not stated; PHFK, primary human foreskin keratinocytes; PHK, primary human keratinocytes, anatomical origin not specified; qPCR, quantitative real-time polymerase chain reaction; VK, vaginal keratinocytes.

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