Review Article
The Role of Airway Epithelial Cells in Response to Mycobacteria Infection
Table 1
Evidenced TLR-related AEC in response to Mtb infection.
| TLRs | Typical Ligands | Cellular location | References |
| TLR1 | Microbial lipoproteins | Cell membrane | [93, 94] | TLR2 | Microbial lipoproteins; PGN; LTA; zymosan; | Cell membrane | [21, 22, 24, 25, 27, 94, 95] | TLR3 | dsRNA | Intracellular components | [95ā97] | TLR4 | LPS; RSV S protein; retroviral envelope protein | Cell membrane | [34] | TLR5 | Flagellin | Cell membrane | [27, 33, 35, 98, 99] | TLR6 | LTA; zymosan; diacyl lipopeptides | Cell membrane | [27, 93, 100] | TLR7 | ssRNA imidazoquinoline | Intracellular components | [95, 101] | TLR8 | ssRNA imidazoquinoline | Intracellular components | [101ā103] | TLR9 | Demethylated CpG DNA | Intracellular components | [60, 98, 101, 104] |
|
|
LPS: lipopolysaccharide; ssRNA: single-stranded RNA; dsRNA: double-stranded RNA; LTA: lipoteichoic acid; PGN: peptidoglycan; RSV: respiratory syncytial virus.
|