Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice
Figure 4
Effect of BPs on urinary protein and serum creatinine levels of MRL-lpr and BALB/c mice. MRL-lpr mice were grouped randomly and treated with BPs 15, 30, and 60 mg·kg−1·day−1, prednisone 5 mg·kg−1·day−1, or model from week 12 to week 24; mice were sacrificed and the supernatant of urine was diluted 1 : 3 in normal saline; the serum creatinine was measured with Jaffe method; data were expressed as means ± S.D. (–8); *, **, *** compared with vehicle-treated model group, tested by ANOVA and Fisher’s PLSD.