Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice
Figure 6
IFN-γ, IL-6, MCP-1, MHC-II, and F4/80 mRNA expression in the kidney from MRL-lpr mice. The mRNA expression of IFN-γ, IL-6, MCP-1, and MHC-II in the kidney was prepared from the BALB/c mice (control) and MRL-lpr mice administered vehicle solution (model), 15, 30, and 60 mg·kg−1·day−1 BPs, or 5 mg·kg−1·day−1 prednisone. The levels of mRNA were analyzed by real-time PCR; GADPH was shown as the loading control. Each data point represented the mean of individual mouse in three independent experiments. Values were presented as means ± S.D. ratio of IFN-γ, IL-6, MCP-1, MHC-II, and F4/80 mRNA to GADPH mRNA (). *, **, *** compared with vehicle-treated model group, tested by ANOVA and Fisher’s PLSD.
