The Impact of Interferon Lambda 3 Gene Polymorphism on Natural Course and Treatment of Hepatitis C
Table 1
Summary of the impact of different IL28B polymorphisms on HCV infection in several conditions (SVR: sustained virological response; RVR: rapid virological response).
Polymorphism
Genotype
Impact on HCV
Impact on HCV/HIV
Impact on liver graft reinfection
rs12979860
C/C
(i) Higher SVR (genotypes 1, 2, 3, 4) [11, 41–45] (ii) Spontaneous clearance [11] (iii) Early viral kinetics [46, 47]
(i) Higher SVR [51] (ii) No influence on acute HCV infection [50] (iii) Higher all-cause mortality [52, 53]
(i) Natural course and treatment outcome dependent on donor rather than recipient genetic background [54] (ii) Higher frequency of posttransplant diabetes mellitus [55]
rs8099917
T/G or T/T
(i) Treatment failure (genotypes 1, 2, 4) [12, 56] (ii) Increased viral clearance and virological response in Taiwanese patients [57]
(i) SVR in patients with recurrent HCV infection [58]
G/G
(i) High prevalence [59] (ii) Treatment failure (genotype 1) [60]
Combined
C/C and T/T
(i) Spontaneous clearance [61] (ii) Early viral kinetics [62, 64, 65] (iii) RVR but not SVR (genotype 3) [63]
