Journal of Immunology Research / 2012 / Article / Fig 4

Research Article

Characterization of Chronic Cutaneous Lesions from TNF-Receptor-1-Deficient Mice Infected by Leishmania major

Figure 4

CCL2, CCL12, and CCL5 in lesions from WT and TNFR1 KO mice infected with L. major. Mice were infected in both footpads with L. major ( ). At 24 and 48 h and at 2, 6, and 11 weeks after infection, mice were killed, lesions were harvested and RT-PCR reactions were performed for chemokines. At 15 weeks, protein was assayed by ELISA. (a–c) Fold increase for CCL2, CCL12, and CCL5 mRNA, obtained by densitometry of bands in gels, as described in Section 2. (d–e) CCL2 and CCL5 determined by ELISA in footpads of naïve mice (NI), and mice infected for 11 and 20 weeks. Data shown are from a single experiment representative of two separate experiments performed with four mice per group. * .

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