Transcription Expression and Clinical Significance of Dishevelled-3 mRNA and 𝜹-Catenin mRNA in Pleural Effusions from Patients with Lung Cancer

Table 4

Accuracy of RT-PCR for detection of DVL-3 mRNA, δ-catenin mRNA and combination of them compared with cytology for the diagnosis of lung cancer.

Variables	Single		Combination of	Cytology
	DVL-3	δ-catenin	DVL-3 plus δ-catenin
Sensitivity (%)	89.3	92.0	100.0*	58.7
Specificity (%)	94.1	90.2	90.2	100.0
Accuracy (%)	91.3	91.3	96.0*	75.4
PPV (%)	95.7	93.2	93.8	100.0
NPV (%)	85.7	88.5	100.0*	62.2

PPV: positive predictive value; NPV: negative predictive value; *P < 0.01 comparing RT-PCR of combination group with cytology.