Regulatory T Cells in HIV Infection: Can Immunotherapy Regulate the Regulator?

Figure 2

The impact of cytokine-based immunotherapy on Treg in HIV infection. The IL-2 immunotherapy results predominantly in the expansion of Treg, which express high levels of the IL-2 receptor chain CD25. In contrast, IL-7 immunotherapy may preferentially favour the effector T cell population without inducing Tregs because Tregs express low levels of the IL-7 receptor chain CD127.