Nonprotein Structures from Mycobacteria: Emerging Actors for Tuberculosis Control
Figure 3
Nonpeptide T-cell antigens associated to the cell wall of Mycobacterium tuberculosis. The amphipathic nature of lipids is mandatory for antigen presentation. The variety of lipids associated to mycobacterial cell envelope include mycolic acids, diacylated sulfatide, glucose monomycolate (GMM), phosphatidyl inositol mannosides (PIM), lipoarabinomannan (LAM), and cell-wall biosynthetic precursors from the isoprenoid family, such as mannosyl phosphopolyprenol (MPP). Restriction to specific CD1 isoforms is indicated.
