Journal of Immunology Research / 2012 / Article / Tab 1

Review Article

CD4+T Cells: Differentiation and Functions

Table 1

Cytokines and transcription factors (the master regulators are underlined).

CD4+ SubsetCytokinesTranscription factorsInhibitory transcription factors

Th1IL12, IFNγT bet, STAT1, STAT4, Runx 3, Eomes, HlxGATA3
Th2IL4, IL2GATA3, STAT6, STAT5, STAT3, Gfi-1, c-Maf, IRF4T-bet, Runx3
Th17IL6, IL 21, IL 23, TGF-βRORγt, STAT3, RORα, Runx1, Batf, IRF4, AHRT-bet+ Runx1, Smad3
Runx1+FOXP3
TfhIL6, IL21Bcl6, STAT3
iTregTGF-β, IL2FOXP3, Smad2, Smad3, STAT5, NFAT
Th9TGF-β, IL4IRF4
Tr1IL27, IL10c-Maf, AhR

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