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Clinical and Developmental Immunology
Volume 2012, Article ID 945950, 5 pages
http://dx.doi.org/10.1155/2012/945950
Review Article

Rituximab-Based Treatment, HCV Replication, and Hepatic Flares

Evangelista Sagnelli,1,2 Mariantonietta Pisaturo,1,2 Caterina Sagnelli,3 and Nicola Coppola1

1Section of Infectious Diseases, Department of Public Medicine, Second University of Naples, 80131 Naples, Italy
2Division of Infectious Diseases, AORN Sant’Anna e San Sebastiano di Caserta, 81100 Caserta, Italy
3Department of Clinical and Experimental Medicine and Surgery “F. Magrassi e A. Lanzara”, Second University of Naples, 80131 Naples, Italy

Received 26 April 2012; Accepted 20 June 2012

Academic Editor: Jürg Schifferli

Copyright © 2012 Evangelista Sagnelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. El Hoofnagle and T. S. Tralka, “Introduction: The National Institutes of Health Consensus Development Conference: management of hepatitis C virus,” Hepatology, vol. 26, no. 3, supplement, pp. 1S–2S, 1997. View at Google Scholar · View at Scopus
  2. A. L. Zignego, D. Macchia, M. Monti et al., “Infection of peripheral mononuclear blood cells by hepatitis C virus,” Journal of Hepatology, vol. 15, no. 3, pp. 382–386, 1992. View at Publisher · View at Google Scholar · View at Scopus
  3. A. L. Zignego, C. Giannini, M. Monti, and L. Gragnani, “Hepatitis C virus lymphotropism: lessons from a decade of studies,” Digestive and Liver Disease, vol. 39, no. 1, pp. S38–S45, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Ferri, F. Caracciolo, A. L. Zignego et al., “Hepatitis C virus infection in patients with non-Hodgkin's lymphoma,” British Journal of Haematology, vol. 88, no. 2, pp. 392–394, 1994. View at Google Scholar · View at Scopus
  5. F. Silvestri, C. Pipan, G. Barillari et al., “Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders,” Blood, vol. 87, no. 10, pp. 4296–4301, 1996. View at Google Scholar · View at Scopus
  6. E. Zuckerman, T. Zuckerman, A. M. Levine et al., “Hepatitis C virus infection in patients with B-cell non-Hodgkin lymphoma,” Annals of Internal Medicine, vol. 127, no. 6, pp. 423–428, 1997. View at Google Scholar · View at Scopus
  7. R. Misiani, P. Bellavita, D. Fenili et al., “Hepatitis C virus infection in patients with essential mixed cryoglobulinemia,” Annals of Internal Medicine, vol. 117, no. 7, pp. 573–577, 1992. View at Google Scholar · View at Scopus
  8. V. Agnello, R. T. Chung, and L. M. Kaplan, “A role for hepatitis C virus infection in Type II cryoglobulinemia,” New England Journal of Medicine, vol. 327, no. 21, pp. 1490–1495, 1992. View at Google Scholar · View at Scopus
  9. P. Marcellin, V. Descamps, M. Martinot-Peignoux et al., “Cryoglobulinemia with vasculitis associated with hepatitis C virus infection,” Gastroenterology, vol. 104, no. 1, pp. 272–277, 1993. View at Google Scholar · View at Scopus
  10. J. Haddad, P. Deny, C. Munz-Gotheil et al., “Lymphocytic sialadenitis of Sjogren's syndrome associated with chronic hepatitis C virus liver disease,” The Lancet, vol. 339, no. 8789, pp. 321–323, 1992. View at Publisher · View at Google Scholar · View at Scopus
  11. J. M. Pawlotsky, F. Roudot-Thoraval, P. Simmonds et al., “Extrahepatic immunologic manifestations in chronic hepatitis C and hepatitis C virus serotypes,” Annals of Internal Medicine, vol. 122, no. 3, pp. 169–173, 1995. View at Google Scholar · View at Scopus
  12. S. C. Gumber and S. Chopra, “Hepatitis C: a multifaceted disease. Review of extrahepatic manifestations,” Annals of Internal Medicine, vol. 123, no. 8, pp. 615–620, 1995. View at Google Scholar · View at Scopus
  13. S. J. Hadziyannis, “The spectrum of extrahepatic manifestations in hepatitis C virus infection,” Journal of Viral Hepatitis, vol. 4, no. 1, pp. 9–28, 1997. View at Google Scholar · View at Scopus
  14. B. D. Clifford, D. Donahue, L. Smith et al., “High prevalence of serological markers of autoimmunity in patients with chronic hepatitis C,” Hepatology, vol. 21, no. 3, pp. 613–619, 1995. View at Google Scholar · View at Scopus
  15. J. Prieto, J. R. Yuste, O. Beloqui et al., “Anticardiolipin antibodies in chronic hepatitis C: implication of hepatitis C virus as the cause of the antiphospholipid syndrome,” Hepatology, vol. 23, no. 2, pp. 199–204, 1996. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Stashenko, L. M. Nadler, R. Hardy, and S. F. Schlossman, “Characterization of a human B lymphocyte-specific antigen,” Journal of Immunology, vol. 125, no. 4, pp. 1678–1685, 1980. View at Google Scholar · View at Scopus
  17. B. D. Cheson, “CHOP plus rituximab—balancing facts and opinion,” New England Journal of Medicine, vol. 346, no. 4, pp. 280–282, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. M. E. Reff, K. Carner, K. S. Chambers et al., “Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20,” Blood, vol. 83, no. 2, pp. 435–445, 1994. View at Google Scholar · View at Scopus
  19. P. McLaughlin, A. J. Grillo-López, B. K. Link et al., “Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program,” Journal of Clinical Oncology, vol. 16, no. 8, pp. 2825–2833, 1998. View at Google Scholar · View at Scopus
  20. D. E. Furst, F. C. Breedveld, J. R. Kalden et al., “Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2007,” Annals of the Rheumatic Diseases, vol. 66, supplement 3, pp. iii2–iii22, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Cacoub, A. Delluc, D. Saadoun, D. A. Landau, and D. Sene, “Anti-CD20 monoclonal antibody (rituximab) treatment for cryoglobulinemia vasculitis: where do we stand?” Annals of the Rheumatic Diseases, vol. 67, no. 3, pp. 283–287, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Saadoun, M. Rosenzwajg, D. Landau, J. C. Piette, D. Klatzmann, and P. Cacoub, “Restoration of peripheral immune homeostasis after rituximab in mixed cryoglobulinemia vasculitis,” Blood, vol. 111, no. 11, pp. 5334–5341, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Aksoy, H. Harputluoglu, S. Kilickap et al., “Rituximab-related viral infections in lymphoma patients,” Leukemia and Lymphoma, vol. 48, no. 7, pp. 1307–1312, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. W. Yeo and P. J. Johnson, “Diagnosis, prevention and management of hepatitis B virus reactivation during anticancer therapy,” Hepatology, vol. 43, no. 2, pp. 209–220, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Loomba, A. Rowley, R. Wesley et al., “Systematic review: the effect of preventive lamivudine on hepatitis B reactivation during chemotherapy,” Annals of Internal Medicine, vol. 148, no. 7, pp. 519–528, 2008. View at Google Scholar · View at Scopus
  26. C. Hsu, C. A. Hsiung, I. J. Su et al., “A revisit of prophylactic lamivudine for chemotherapy-associated hepatitis B reactivation in non-Hodgkin's lymphoma: a randomized trial,” Hepatology, vol. 47, no. 3, pp. 844–853, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. T. N. Palmore, N. L. Shah, R. Loomba et al., “Reactivation of hepatitis B with reappearance of hepatitis B surface antigen after chemotherapy and immunosuppression,” Clinical Gastroenterology and Hepatology, vol. 7, no. 10, pp. 1130–1137, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. N. Fukushima, T. Mizuta, M. Tanaka et al., “Retrospective and prospective studies of hepatitis B virus reactivation in malignant lymphoma with occult HBV carrier,” Annals of Oncology, vol. 20, no. 12, pp. 2013–2017, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. W. Yeo, T. C. Chan, N. W. Y. Leung et al., “Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab,” Journal of Clinical Oncology, vol. 27, no. 4, pp. 605–611, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. S. N. Pei, C. H. Chen, C. M. Lee et al., “Reactivation of hepatitis B virus following rituximab-based regimens: a serious complication in both HBsAg-positive and HBsAg-negative patients,” Annals of Hematology, vol. 89, no. 3, pp. 255–262, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. X. Koo, D. S. W. Tan, I. B. Tan, M. Tao, W. C. Chow, and S. T. Lim, “Hepatitis B virus reactivation and role of antiviral prophylaxis in lymphoma patients with past hepatitis B virus infection who are receiving chemoimmunotherapy,” Cancer, vol. 116, no. 1, pp. 115–121, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Marzano, E. Angelucci, P. Andreone et al., “Prophylaxis and treatment of hepatitis B in immunocompromised patients,” Digestive and Liver Disease, vol. 39, no. 5, pp. 397–408, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. N. Coppola, G. Tonziello, M. Pisaturo et al., “Reactivation of overt and occult hepatitis B infection in various immunosuppressive settings,” Journal of Medical Virology, vol. 83, no. 11, pp. 1909–1916, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Aksoy, H. Abali, S. Kilickap, M. Erman, and A. Kars, “Accelerated hepatitis C virus replication with rituximab treatment in a non-Hodgkin's lymphoma patient,” Clinical and Laboratory Haematology, vol. 28, no. 3, pp. 211–214, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Nooka, P. J. Shenoy, R. Sinha, S. Lonial, and C. R. Flowers, “Hepatitis C reactivation in patients who have diffuse large B-cell lymphoma treated with rituximab: a case report and review of literature,” Clinical Lymphoma, Myeloma and Leukemia, vol. 11, no. 5, pp. 379–384, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. D. Ennishi, Y. Maeda, N. Niitsu et al., “Hepatic toxicity and prognosis in hepatitis C virus-infected patients with diffuse large B-cell lymphoma treated with rituximab-containing chemotherapy regimens: a Japanese multicenter analysis,” Blood, vol. 116, no. 24, pp. 5119–5125, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. Y. Tsutsumi, K. Ichiki, S. Shiratori et al., “Changes in hepatitis C virus antibody titer and viral RNA load in non-Hodgkin's lymphoma patients after rituximab chemotherapy,” International Journal of Laboratory Hematology, vol. 31, no. 4, pp. 468–470, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. V. Pitini, G. Sturniolo, C. Arrigo, S. Leonardi, S. Pino, and G. Altavilla, “HCV genotype 2 as a risk factor for reactivation in patients with B-cell lymphoma undergoing rituximab combination chemotherapy: correspondence,” British Journal of Haematology, vol. 150, no. 1, pp. 116–118, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Marignani, M. Mangone, M. C. Cox et al., “HCV-positive status and hepatitis flares in patients with B-cell non-Hodgkin's lymphoma treated with rituximab-containing regimens,” Digestive and Liver Disease, vol. 43, no. 2, pp. 139–142, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. N. Coppola, M. Pisaturo, S. Guastafierro et al., “Increased hepatitis C viral load and reactivation of liver disease in HCV RNA-positive patients with onco-haematological disease undergoing chemotherapy,” Digestive and Liver Disease, vol. 44, no. 1, pp. 49–54, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. C. Y. Hsieh, H. H. Huang, C. Y. Lin et al., “Rituximab-induced hepatitis C virus reactivation after spontaneous remission in diffuse large B-cell lymphoma,” Journal of Clinical Oncology, vol. 26, no. 15, pp. 2584–2586, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. G. Lake-Bakaar, L. Dustin, J. McKeating, K. Newton, V. Freeman, and S. D. W. Frost, “Hepatitis C virus and alanine aminotransferase kinetics following B-lymphocyte depletion with rituximab: evidence for a significant role of humoral immunity in the control of viremia in chronic HCV liver disease,” Blood, vol. 109, no. 2, pp. 845–846, 2007. View at Google Scholar · View at Scopus
  43. L. Arcaini, M. Merli, F. Passamonti et al., “Impact of treatment-related liver toxicity on the outcome of HCV-positive non-Hodgkin's lymphomas,” American Journal of Hematology, vol. 85, no. 1, pp. 46–50, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. A. Petrarca, L. Rigacci, P. Caini et al., “Safety and efficacy of rituximab in patients with hepatitis C virus-related mixed cryoglobulinemia and severe liver disease,” Blood, vol. 116, no. 3, pp. 335–342, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. G. J. Silverman and S. Weisman, “Rituximab therapy and autoimmune disorders: prospects for anti-B cell therapy,” Arthritis and Rheumatism, vol. 48, no. 6, pp. 1484–1492, 2003. View at Publisher · View at Google Scholar · View at Scopus
  46. S. Ciesek, E. Steinmann, M. Iken et al., “Glucocorticosteroids Increase Cell Entry by Hepatitis C Virus,” Gastroenterology, vol. 138, no. 5, pp. 1875–1884, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. M. B. Zeisel, I. Fofana, S. Fafi-Kremer, and T. F. Baumert, “Hepatitis C virus entry into hepatocytes: molecular mechanisms and targets for antiviral therapies,” Journal of Hepatology, vol. 54, no. 3, pp. 566–576, 2011. View at Publisher · View at Google Scholar · View at Scopus
  48. C. Visco, L. Arcaini, E. Brusamolino et al., “Distinctive natural history in hepatitis C virus positive diffuse large B-cell lymphoma: analysis of 156 patients from northern Italy,” Annals of Oncology, vol. 17, no. 9, pp. 1434–1440, 2006. View at Publisher · View at Google Scholar · View at Scopus
  49. N. Coppola, M. Pisaturo, S. Guastafierro et al., “Absence of occult hepatitis C virus infection in patients under immunosupressive therapy for oncohematological diseases,” Hepatology, vol. 54, no. 4, pp. 1487–1489, 2011. View at Publisher · View at Google Scholar · View at Scopus