Table 5: Biological networks in kidney graft tissues that are associated with BKVN.

GO termGenes annotatedP value*

Negative regulation of transcriptionGO:0048661 EDN1, TNF 0.003
Positive regulation of NF kappa B transcriptionGO:0016481TGFB1, TNF 0.004
Activation of MAPK activityGO:0051092 IKBKB, TGFB1, TNF 0.005
Positive regulation of phosphorylationGO:0000187 IL1B, TNF 0.007
Intracellular signal transductionGO:0001934 IL1B, TNF 0.007
Negative regulation of viral genome replicationGO:0007242 CD80, IL8 0.008
Signal transducer activityGO:0045071 CCL5, TNF 0.010
Organ morphogenesisGO:0004871 CCL2, CCL3, CCL5, HMOX1, IL12B, IL13, IL15, IL18, IL1A, IL1B, STAT3 0.011
Positive regulation of transription, DNA dependentGO:0009887 CCL2, IL7, TGFB1, TNF 0.011
Transcription activator activityGO:0045941 CD80, CD86, TNF 0.011
ExocytosisGO:0016563 CD80, CD86, IKBKB, TGFB1 0.011
Chemoattractant activityGO:0006887 CCL3, CCL5 0.013
AngiogenesisGO:0042056 CCL3, CCL5 0.013
Induction of positive chemotaxisGO:0001525 IL18, IL1B, IL8, VEGF 0.013
Regulation of cell adhesionGO:0050930 IL8, VEGF 0.015
Regulation of isotype switchingGO:0030183 IL10, IL4 0.015
Regulation of cell adhesionGO:0045191 IL10, IL4 0.015
Response to oxidative stressGO:0030155 ICAM1, IL18, IL8 0.016
Protein phosphorylationGO:0006979 CCL5, PTGS2 0.016
Positive regulation of T helper 2 cell differentiationGO:0006468 CCL2, IKBKB, TGFB1 0.017
Cellular component movementGO:0045630 CD86, IL6 0.018
Positive regulation of B cell proliferationGO:0006928 ACTB, CCL3, CCL5, CXCR3, IFNG, IL13, IL8, PTGS2, STAT3 0.019
Cellular calcium ion homeostasisGO:0030890 IL4, IL7, PTPRC 0.019
Chemokine activityGO:0006874 CCL19, CCL2, CCL3, CCL5 0.022
Response to glucocorticoid stimulusGO:0008009 CCL19, CCL2, CCL3, CCL5, CXCL10, CXCL11, IL8 0.024
Positive regulationof T cell proliferationGO:0051384 IL10, IL6, TNF 0.024
T cell differentiationGO:0042102 CD28, CD3E, IL12A, IL4, PTPRC 0.024
Defense response to virusGO:0030217 IL2, PTPRC 0.025
Induction of apoptosis by extracellular signalsGO:0051607 BCL2, PTPRC 0.026
Negative regulation of transcription from RNA polymerase II promoterGO:0008624 CD38, FAS, FASLG 0.027
Positive regulation of protein kinase activityGO:0000122 SMAD3, STAT3, TNF 0.030
Response to virusGO:0045860 CD4, PTPRC 0.033
Negative regulation of cytokine secretion involved in immune responseGO:0009615 CCL19, CCL5, IFNG, TNF 0.033
Negative regulation of interleukin-6 productionGO:0002740 IL10, TNF 0.033
Receptor biosynthetic processGO:0032715 IL10, TNF 0.033
Positive regulation of cytokine productionGO:0032800 IL10, TNF 0.033
Positive regulation of transcription from RNA polymerase II promoterGO:0050715 IL10, TNF 0.033
Positive regulation of isotype switching to IgG isotypesGO:0045944 IL4, IL6, SMAD3, TNF 0.034
Regulation of immune responseGO:0048304 IFNG, IL4, TBX21 0.035
Activation of caspase activityGO:0050776 IFNG, IL4, TBX21 0.035
Receptor bindingGO:0006919 BAX, SMAD3, TNF 0.035
Antigen processing and presentationGO:0005102C3, REN 0.038
Activation a proapoptotic gene productsGO:0019882 CD8A, IFNG 0.038
Cell cycle arrestGO:0008633 BCL2, FAS, FASLG 0.039
Protein kinase bindingGO:0007050 IFNG, IL12A, IL12B, IL8, SMAD3, TGFB1 0.042
Cell adhesionGO:0019901 CD3E, CD4, PTPRC 0.043
JAK-STAT cascadeGO:0007155 CCL2, CCL5, CD34, CD4, CXCR3, FN1, SELE, SELP 0.044
Plasma membraneGO:0007259 CCL2, CCR2, STAT3 0.046
Neutrophil chemotaxisGO:0005886 ACE, AGTR1, AGTR2, CCR2, CCR4, CCR5, CCR7, CD19, CD28, CD34, CD38, CD3E, CD4, CD40, CD40LG, CD80, CD86, CD8A, CSF1, CXCR3, FAS, FASLG, ICAM1, ICOS, IL2RA, PTPRC, SELE, SELP, TFRC, TNF, TNFRSF18 0.046
Positive regulation of interleukin-2 biosynthetic processGO:0045086IFNG, IL1B, IL8 0.046

* P values by ANOVA followed by Bonferroni adjustment.