Molecular Networks Involved in the Immune Control of BK Polyomavirus

Table 5

Biological networks in kidney graft tissues that are associated with BKVN.

GO term		Genes annotated	P value*
Negative regulation of transcription	GO:0048661	EDN1, TNF	0.003
Positive regulation of NF kappa B transcription	GO:0016481	TGFB1, TNF	0.004
Activation of MAPK activity	GO:0051092	IKBKB, TGFB1, TNF	0.005
Positive regulation of phosphorylation	GO:0000187	IL1B, TNF	0.007
Intracellular signal transduction	GO:0001934	IL1B, TNF	0.007
Negative regulation of viral genome replication	GO:0007242	CD80, IL8	0.008
Signal transducer activity	GO:0045071	CCL5, TNF	0.010
Organ morphogenesis	GO:0004871	CCL2, CCL3, CCL5, HMOX1, IL12B, IL13, IL15, IL18, IL1A, IL1B, STAT3	0.011
Positive regulation of transription, DNA dependent	GO:0009887	CCL2, IL7, TGFB1, TNF	0.011
Transcription activator activity	GO:0045941	CD80, CD86, TNF	0.011
Exocytosis	GO:0016563	CD80, CD86, IKBKB, TGFB1	0.011
Chemoattractant activity	GO:0006887	CCL3, CCL5	0.013
Angiogenesis	GO:0042056	CCL3, CCL5	0.013
Induction of positive chemotaxis	GO:0001525	IL18, IL1B, IL8, VEGF	0.013
Regulation of cell adhesion	GO:0050930	IL8, VEGF	0.015
Regulation of isotype switching	GO:0030183	IL10, IL4	0.015
Regulation of cell adhesion	GO:0045191	IL10, IL4	0.015
Response to oxidative stress	GO:0030155	ICAM1, IL18, IL8	0.016
Protein phosphorylation	GO:0006979	CCL5, PTGS2	0.016
Positive regulation of T helper 2 cell differentiation	GO:0006468	CCL2, IKBKB, TGFB1	0.017
Cellular component movement	GO:0045630	CD86, IL6	0.018
Positive regulation of B cell proliferation	GO:0006928	ACTB, CCL3, CCL5, CXCR3, IFNG, IL13, IL8, PTGS2, STAT3	0.019
Cellular calcium ion homeostasis	GO:0030890	IL4, IL7, PTPRC	0.019
Chemokine activity	GO:0006874	CCL19, CCL2, CCL3, CCL5	0.022
Response to glucocorticoid stimulus	GO:0008009	CCL19, CCL2, CCL3, CCL5, CXCL10, CXCL11, IL8	0.024
Positive regulationof T cell proliferation	GO:0051384	IL10, IL6, TNF	0.024
T cell differentiation	GO:0042102	CD28, CD3E, IL12A, IL4, PTPRC	0.024
Defense response to virus	GO:0030217	IL2, PTPRC	0.025
Induction of apoptosis by extracellular signals	GO:0051607	BCL2, PTPRC	0.026
Negative regulation of transcription from RNA polymerase II promoter	GO:0008624	CD38, FAS, FASLG	0.027
Positive regulation of protein kinase activity	GO:0000122	SMAD3, STAT3, TNF	0.030
Response to virus	GO:0045860	CD4, PTPRC	0.033
Negative regulation of cytokine secretion involved in immune response	GO:0009615	CCL19, CCL5, IFNG, TNF	0.033
Negative regulation of interleukin-6 production	GO:0002740	IL10, TNF	0.033
Receptor biosynthetic process	GO:0032715	IL10, TNF	0.033
Positive regulation of cytokine production	GO:0032800	IL10, TNF	0.033
Positive regulation of transcription from RNA polymerase II promoter	GO:0050715	IL10, TNF	0.033
Positive regulation of isotype switching to IgG isotypes	GO:0045944	IL4, IL6, SMAD3, TNF	0.034
Regulation of immune response	GO:0048304	IFNG, IL4, TBX21	0.035
Activation of caspase activity	GO:0050776	IFNG, IL4, TBX21	0.035
Receptor binding	GO:0006919	BAX, SMAD3, TNF	0.035
Antigen processing and presentation	GO:0005102	C3, REN	0.038
Activation a proapoptotic gene products	GO:0019882	CD8A, IFNG	0.038
Cell cycle arrest	GO:0008633	BCL2, FAS, FASLG	0.039
Protein kinase binding	GO:0007050	IFNG, IL12A, IL12B, IL8, SMAD3, TGFB1	0.042
Cell adhesion	GO:0019901	CD3E, CD4, PTPRC	0.043
JAK-STAT cascade	GO:0007155	CCL2, CCL5, CD34, CD4, CXCR3, FN1, SELE, SELP	0.044
Plasma membrane	GO:0007259	CCL2, CCR2, STAT3	0.046
Neutrophil chemotaxis	GO:0005886	ACE, AGTR1, AGTR2, CCR2, CCR4, CCR5, CCR7, CD19, CD28, CD34, CD38, CD3E, CD4, CD40, CD40LG, CD80, CD86, CD8A, CSF1, CXCR3, FAS, FASLG, ICAM1, ICOS, IL2RA, PTPRC, SELE, SELP, TFRC, TNF, TNFRSF18	0.046
Positive regulation of interleukin-2 biosynthetic process	GO:0045086	IFNG, IL1B, IL8	0.046

* P values by ANOVA followed by Bonferroni adjustment.