Table of Contents Author Guidelines Submit a Manuscript
Clinical and Developmental Immunology
Volume 2013, Article ID 132432, 8 pages
http://dx.doi.org/10.1155/2013/132432
Research Article

Haemophilus parasuis Subunit Vaccines Based on Native Proteins with Affinity to Porcine Transferrin Prevent the Expression of Proinflammatory Chemokines and Cytokines in Pigs

1Unidad de Microbiología e Inmunología, Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, 24007 León, Spain
2Laboratório de Imunologia e Doenças Infecto-Contagiosas, Faculdade de Agronomia e Medicina Veterinária, Universidade de Passo Fundo, 99052-900 Passo Fundo, RS, Brazil
3Instituto Tecnológico Agrario de Castilla y León (ITACyL), 47071 Valladolid, Spain

Received 3 July 2013; Revised 22 August 2013; Accepted 27 September 2013

Academic Editor: Roy Ambli Dalmo

Copyright © 2013 R. Frandoloso et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Medzhitov and C. Janeway Jr., “Innate immune recognition: mechanisms and pathways,” Immunological Reviews, vol. 173, pp. 89–97, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Frandoloso, S. Martínez-Martínez, S. Yubero, E. F. Rodríguez-Ferri, and C. B. Gutiérrez Martín, “New insights in cellular immune response in colostrum-deprived pigs after immunization with subunit and commercial vaccines against Glässer's disease,” Cell Immunology, vol. 277, pp. 74–82, 2012. View at Google Scholar
  3. M. J. Baarsch, R. W. Scamurra, K. Burger, D. L. Foss, S. K. Maheswaran, and M. P. Murtaugh, “Inflammatory cytokine expression in swine experimentally infected with Actinobacillus pleuropneumoniae,” Infection and Immunity, vol. 63, no. 9, pp. 3587–3594, 1995. View at Google Scholar · View at Scopus
  4. C. Choi, D. Kwon, K. Jung et al., “Expression of inflammatory cytokines in pigs experimentally infected with Mycoplasma hyopneumoniae,” Journal of Comparative Pathology, vol. 134, no. 1, pp. 44–50, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. A. J. Martín de la Fuente, E. F. Rodríguez Ferri, F. Tejerina, R. Frandoloso, S. Martínez, and C. B. Gutiérrez Martín, “Cytokine expression in colostrum-deprived pigs immunized and challenged with Haemophilus parasuis,” Research in Veterinary Science, vol. 87, pp. 47–52, 2009. View at Google Scholar
  6. D. K. Dalton, S. Pitts-Meek, S. Keshav, I. S. Figari, A. Bradley, and T. A. Stewart, “Multiple defects of immune cell function in mice with disrupted interferon-γ genes,” Science, vol. 259, no. 5102, pp. 1739–1742, 1993. View at Google Scholar · View at Scopus
  7. B. Zhao, S. A. Stavchansky, R. A. Bowden, and P. D. Bowman, “Effect of interleukin-1β and tumor necrosis factor-α on gene expression in human endothelial cells,” The American Journal of Physiology, vol. 284, no. 6, pp. C1577–C1583, 2003. View at Google Scholar · View at Scopus
  8. S. Safaya, M. H. Steinberg, and E. S. Klings, “Monocytes from sickle cell disease patients induce differential pulmonary endothelial gene expression via activation of NF-κB signaling pathway,” Molecular Immunology, vol. 50, no. 1-2, pp. 117–123, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Kishimoto, “The biology of interleukin-6,” Blood, vol. 74, no. 1, pp. 1–10, 1989. View at Google Scholar · View at Scopus
  10. J. Catusse, P. Faye, B. Loillier et al., “Cloning and characterization of guinea pig interleukin-8 receptor,” Biochemical Pharmacology, vol. 66, no. 7, pp. 1171–1180, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. B. Beutler, “Sepsis begins at the interface of pathogen and host,” Biochemical Society Transactions, vol. 29, no. 6, pp. 853–859, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. R. de Waal Malefyt, J. Abrams, B. Bennett, C. G. Figdor, and J. E. de Vries, “Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes,” Journal of Experimental Medicine, vol. 174, no. 5, pp. 1209–1220, 1991. View at Google Scholar · View at Scopus
  13. D. F. Fiorentino, A. Zlotnik, T. R. Mosmann, M. Howard, and A. O'Garra, “IL-10 inhibits cytokine production by activated macrophages,” Journal of Immunology, vol. 147, no. 11, pp. 3815–3822, 1991. View at Google Scholar · View at Scopus
  14. I. Blanco, L. Galina-Pantoja, S. Oliveira, C. Pijoan, C. Sánchez, and A. Canals, “Comparison between Haemophilus parasuis infection in colostrums-deprived and sow-reared piglets,” Veterinary Microbiology, vol. 103, no. 1-2, pp. 21–27, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Frandoloso, S. Martínez, E. F. Rodríguez-Ferri et al., “Development and characterization of protective Haemophilus parasuis subunit vaccines based on native proteins with affinity to porcine transferrin and comparison with other subunit and commercial vaccines,” Clinical and Vaccine Immunology, vol. 18, pp. 50–58, 2011. View at Google Scholar
  16. S. A. Bustin, V. Benes, J. A. Garson et al., “The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments,” Clinical Chemistry, vol. 55, no. 4, pp. 611–622, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. Statistix 8. 0: User's Manual, Analytical software, Tallahasse, Fla, USA, 2003.
  18. R. E. Gerszten, E. A. Garcia-Zepeda, Y.-C. Lim et al., “MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions,” Nature, vol. 398, no. 6729, pp. 718–725, 1999. View at Publisher · View at Google Scholar · View at Scopus
  19. B. Bouchet, G. Vanier, M. Jacques, and M. Gottschalk, “Interactions of Haemophilus parasuis and its LOS with porcine brain microvascular endothelial cells,” Veterinary Research, vol. 39, no. 5, pp. 42–47, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. B. Bouchet, G. Vanier, M. Jacques, E. Auger, and M. Gottschalk, “Studies on the interactions of Haemophilus parasuis with porcine epithelial tracheal cells: limited role of LOS in apoptosis and pro-inflammatory cytokine release,” Microbial Pathogenesis, vol. 46, no. 2, pp. 108–113, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Rider, Y. Carmi, O. Guttman et al., “IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation,” Journal of Immunology, vol. 187, no. 9, pp. 4835–4843, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. A. J. Martín de la Fuente, R. Carpintero, E. F. Rodríguez Ferri, M. A. Álava, F. Lampreave, and C. B. Gutiérrez Martín, “Acute-phase protein response in pigs experimentally infected with Haemophilus parasuis,” Comparative Immunology Microbiology and Infectious Diseases, vol. 33, pp. 455–465, 2010. View at Google Scholar
  23. S. Martínez Martínez, R. Frandoloso, C. B. Gutiérrez Martín et al., “Acute phase protein concentrations in colostrum-deprived pigs immunized with subunit and commercial vaccines against Glässer's disease,” Veterinary Immunology and Immunopathology, vol. 144, pp. 61–67, 2011. View at Google Scholar
  24. R. V. Luckheeram, R. Zhou, A. D. Verma, and B. Xia, “CD4+T cells: differentiation and functions,” Clinical and Developmental Immunology, vol. 2012, Article ID 925135, 12 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. E. Bartoccioni, F. Scuderi, M. Marino, and C. Provenzano, “IL-6, monocyte infiltration and parenchymal cells,” Trends in immunology, vol. 24, no. 6, pp. 299–300, 2003. View at Google Scholar · View at Scopus
  26. M. Michishita, Y. Yoshida, H. Uchino, and K. Nagata, “Induction of tumor necrosis factor-α and its receptors during differentiation in myeloid leukemic cells along the monocytic pathway: a possible regulatory mechanism for TNF-α production,” Journal of Biological Chemistry, vol. 265, no. 15, pp. 8751–8759, 1990. View at Google Scholar · View at Scopus
  27. H. Cho and D. N. McMurray, “Neutralization of tumor necrosis factor alpha suppresses antigen-specific type 1 cytokine responses and reverses the inhibition of mycobacterial survival in cocultures of immune guinea pig T lymphocytes and infected macrophages,” Infection and Immunity, vol. 73, no. 12, pp. 8437–8441, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Cerami, “Inflamatory cytokines,” Clinical Immunology and Immunopathology, vol. 62, pp. S3–S10, 1992. View at Google Scholar
  29. N. F. Go, B. E. Castle, R. Barrett et al., “Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells,” Journal of Experimental Medicine, vol. 172, no. 6, pp. 1625–1631, 1990. View at Publisher · View at Google Scholar · View at Scopus
  30. J. C. Duvigneau, R. T. Hartl, S. Groiss, and M. Gemeiner, “Quantitative simultaneous multiplex real-time PCR for the detection of porcine cytokines,” Journal of Immunological Methods, vol. 306, no. 1-2, pp. 16–27, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. C. Arce, M. Ramírez-Boo, C. Lucena, and J. J. Garrido, “Innate immune activation of swine intestinal epithelial cell lines (IPEC-J2 and IPI-2I) in response to LPS from Salmonella typhimurium,” Comparative Immunology, Microbiology and Infectious Diseases, vol. 33, no. 2, pp. 161–174, 2010. View at Publisher · View at Google Scholar · View at Scopus