Involvement of MicroRNA in Microglia-Mediated Immune Response

Table 1

MiRNAs in microglia and macrophage activation.

	Role	Phenotype	Ref
↑ miR-155	Targets SOCS-1 causing ↑ of iNOS, TNF-𝛼, IL-6, and IFN-β; Targets SMAD2 and CEBPβ	M1	[18, 36, 40]
↑ miR-124	Lead to ↓ IL-6, iNOS, and TNF-𝛼 and ↑ TGF-𝛽, arginase-1, and FIZZ1	M2	[33, 34]
↑ miR-101	↓ MPK-1 promoting MAPK activation and IL-6, TNF-𝛼, and IL-1 expression	M1	[42]
↑ miR-125b	↑ MHC class II, CD40, CD80, and CD86 through targeting of IFR4; Elevates responsiveness to IFN-𝛾	M1	[43]
↓ miR-92a	Inhibited activation of JNK/c-Jun through targeting of MKK4; Its downregulation is necessary to promote the M1 phenotype	M1	[44]