Review Article
Involvement of MicroRNA in Microglia-Mediated Immune Response
Table 1
MiRNAs in microglia and macrophage activation.
| | Role | Phenotype | Ref |
| miR-155 | Targets SOCS-1 causing of iNOS, TNF-, IL-6, and IFN-β Targets SMAD2 and CEBPβ | M1
| [18, 36, 40] |
| miR-124 | Lead to IL-6, iNOS, and TNF- and TGF-, arginase-1, and FIZZ1 | M2
| [33, 34] |
| miR-101 | MPK-1 promoting MAPK activation and IL-6, TNF-, and IL-1 expression | M1 | [42] |
| miR-125b | MHC class II, CD40, CD80, and CD86 through targeting of IFR4 Elevates responsiveness to IFN- | M1
| [43] |
| miR-92a | Inhibited activation of JNK/c-Jun through targeting of MKK4 Its downregulation is necessary to promote the M1 phenotype | M1
| [44] |
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