Low-Dose Amphotericin B and Murine Dialyzable Spleen Extracts Protect against Systemic Candida Infection in Mice

Figure 3

Effects of low-dose AmB and mDSE on kidney and serum cytokines in systemic candidiasis. Mice were infected with 5 × 10⁵ CFU of Ca07-387 and treated with 10 pg of mDSE in combination with 0.1 mg/kg of AmB. (a) IFN-γ, (b) TGF-β1, (c) IL-6, (d) IL-10, and (e) TNF-α were measured in macerated kidneys. Each point represents mean and SD of three mice. (f) Serum IL-6 and (g) serum hepcidin in each experimental group: each point represents mean and SD of three mice. **𝑃<0.01, ***𝑃<0.001, AmB versus AmB + mDSE.

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