Polyomavirus JC in the Context of Immunosuppression: A Series of Adaptive, DNA Replication-Driven Recombination Events in the Development of Progressive Multifocal Leukoencephalopathy
Figure 1
DNA deletions and duplication in a JCV archetype sequence leading to a Mad-1 sequence implicated in PML: position of an internal palindrome. (a) The sequence of the noncoding control region (NCCR) termed archetype [31] here is from strain JAL (gb:JX273163). The sequence rearrangements leading to Mad-1 have been documented [28, 39]. The core origin of DNA replication (ori, not altered) is shaded in light blue. A 23 bp deletion is shaded in red. A 66 bp deletion is shaded in yellow. After shown deletions, the sequence underlined and in bold is tandemly duplicated in Mad-1. (b) A potentially stable internal hairpin, positioned at the 5′ end of the 66 bp deletion, is typed in blue and boxed. A sequence most frequently deleted in several reported cases of PML [4] is located within the 66 bp deletion and typed in red.
