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Clinical and Developmental Immunology
Volume 2013, Article ID 256462, 8 pages
http://dx.doi.org/10.1155/2013/256462
Research Article

Decreased PERP Expression on Peripheral Blood Mononuclear Cells from Patient with Rheumatoid Arthritis Negatively Correlates with Disease Activity

1The First Hospital of Xiamen University, Xiamen 361003, China
2Division of Rheumatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
3British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK
4Department of Immunology, Chengdu Medical College, Chengdu 610000, China
5Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China

Received 4 May 2013; Accepted 20 July 2013

Academic Editor: Jianying Zhang

Copyright © 2013 Yanchun Du et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. PERP, p53 apoptosis effector related to PMP-22, is a p53-dependent apoptosis in diverse cell types and has cell type-specific roles in p53-mediated apoptosis. However, its role in PBMCs of RA patients has remained largely unclear. Objectives. The aim of this study was to detect the expression levels of PERP on PBMCs of RA patients and healthy controls and analyze the role of PERP in the pathogenesis of RA. Methods. The mRNA expression levels of PERP and IL-17 were detected by real-time PCR in PBMCs from patients with RA ( ) and healthy controls ( ). The correlations of PERP expression levels to IL-17 transcripts and disease activity parameters were analyzed. Results. The PERP and IL-17 expression levels in the PBMCs were significantly decreased and increased in comparison of which in healthy controls. The mRNA expression levels of PERP in PBMCs from patients with RA were negatively correlated with IL-17 and disease activity parameters DAS28, RF, CRP, and ESR rather than Anti-CCP and ANA. Conclusions. These results demonstrated that PERP might be involved in the pathogenesis and a potential therapeutic target of RA by regulating the expression of IL-17.