Role of Th17 Cells in Skin Inflammation of Allergic Contact Dermatits

Table 1

Summary of studies on human Th17 cells. T-cell lines were derived from skin biopsies by limiting dilution and further specified for CD4 or not. Skin cells were analyzed without specification of the phenotype. In some studies, coexpression of IL-17 with cytokines specific for Th1, Th2, or Th22 was analyzed by flow cytometry.

T-cell subset	Patients	Hapten	Cytokines detected	Coexpression analyzed	Reference
CD4^+ T cells	ACD	NiSO4	IL-17, IFN-𝛾, TNF-𝛼	No	[71]
CD4^+ CD45^+ T cells	ACD	NiCl2	IL-17, IFN-𝛾	No	[72]
T cells	Psoriasis, ACD	NiSO4	IL-17, IFN-𝛾, IL-22, IL-4	No	[73]
T cells	ACD	Fragrances	IL-17, IFN-𝛾, IL-22, IL-4	Yes	[74]
T cells	ACD	NiSO4	IL-17, IFN-𝛾, IL-4	Yes	[74]
T cells	ACD	Nickel	IL-17, IFN-𝛾, IL-22, IL-4	Yes	[75]
Skin cells	ACD	Nickel	IL-17, IFN-𝛾	No	[76]