Treatment with CB2 Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice
Figure 4
The treatment with JWH-133 increased NO bioavailability in the corpus cavernosum of ApoE−/− mice. Relaxation produced by increasing cumulative concentrations of acetylcholine (a) in cavernosal strip from wild type mice and untreated and JWH-133-treated ApoE−/− mice. ((b)-(c)) Constriction induced by cumulative concentrations of phenylephrine in the presence (c) or absence (b) of NOS inhibitor (L-NAME) in cavernosal strip. (d) Normalized curve response of phenylephrine in the presence of L-NAME by phenylephrine response at 10−6 mol/L. *, **, and *** (two-way ANOVA followed by the Bonferroni multiple comparison test). Each point represents the mean ± SEM ( to 10). n.s.: nonsignificant.