Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL/lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease
Figure 5
Increase in BIRC5 expression in immature cells. Nine-week-old mice were treated with metoclopramide (200 μg/100 μL) to induce hyperprolactinaemia (HyperPRL) or PBS (100 μL) for 6 weeks. At the end of the treatment, pro-B, pre-B and immature B cells were purified using flow cytometry in three independent experiments using three mice per experiment. Using RT-PCR, the BIRC5 mRNA expression was determined. (a) C57BL/6 mice; (b) MRL mice; (c) MRL/lpr mice. The asterisks denote statistical significance between populations with the value shown.
