Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL/lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease

Table 1

SLE manifestations in mice with hyperprolactinemia.

Strain	C57BL/6			MRL			MRL/lpr
Treatment	9 weeks	PBS	HyperPRL	9 weeks	PBS	HyperPRL	9 weeks	PBS	HyperPRL
PRL (ng/mL)	4.2±1.3	3.8±1.1	10.7±1.2^∗	12.5±1.9	11.2±1.8	26.27±2.9^∗	12.7±2.2	20.0±2.7^∗	34.5±4.3^∗
Proteinuria (mg/mL)	0	0	0	10.1±7.2	12.8±5.6	121.6±37.4^∗	13.5±8.5	48.0±18.6^∗	166.6±23.5^∗
Ab anti-dsDNA (𝜇g/mL)	0	0	0	0	5.9±1.9^∗	22.9±5.1^∗	2.5±0.05	11.6±1.2^∗	22.5±5.1^∗

HyperPRL: hyperprolactinemia.
*ANOVA, 𝑃<0.05.