Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 294320, 9 pages
http://dx.doi.org/10.1155/2013/294320
Interleukin-19 in Breast Cancer
1Department of Medical Research, Chi-Mei Medical Center, Tainan 710, Taiwan
2Department of Anesthesiology, Chi-Mei Medical Center, Tainan 710, Taiwan
3Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan
4Department of Pathology, Chi-Mei Medical Center, Tainan 710, Taiwan
5Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan 711, Taiwan
6Institute of Biochemistry and Molecular Biology, Medical College, National Cheng Kung University, Tainan 701, Taiwan
7Department of Anesthesiology, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Received 13 January 2013; Revised 22 March 2013; Accepted 29 March 2013
Academic Editor: Nima Rezaei
Copyright © 2013 Ying-Yin Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- D. G. DeNardo and L. M. Coussens, “Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression,” Breast Cancer Research, vol. 9, no. 4, p. 212, 2007. View at Google Scholar · View at Scopus
- V. S. Rao, C. E. Dyer, J. K. Jameel, P. J. Drew, and J. Greenman, “Potential prognostic and therapeutic roles for cytokines in breast cancer (Review),” Oncology Reports, vol. 15, no. 1, pp. 179–185, 2006. View at Google Scholar · View at Scopus
- L. S. Lindstrom, E. Karlsson, U. M. Wilking et al., “Clinically used breast cancer markers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are unstable throughout tumor progression,” Journal of Clinical Oncology, vol. 30, no. 21, pp. 2601–2608, 2012. View at Google Scholar
- K. Yao-Lung, C. Dar-Ren, and C. Tsai-Wang, “Clinicopathological features of triple-negative breast cancer in Taiwanese women,” International Journal of Clinical Oncology, vol. 15, no. 5, pp. 500–505, 2011. View at Publisher · View at Google Scholar · View at Scopus
- B. L. Pierce, R. Ballard-Barbash, L. Bernstein et al., “Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients,” Journal of Clinical Oncology, vol. 27, no. 21, pp. 3437–3444, 2009. View at Publisher · View at Google Scholar · View at Scopus
- A. Mantovani, F. Marchesi, C. Porta, A. Sica, and P. Allavena, “Inflammation and cancer: breast cancer as a prototype,” Breast, vol. 16, supplement 2, pp. 27–33, 2007. View at Publisher · View at Google Scholar · View at Scopus
- A. Nicolini, A. Carpi, and G. Rossi, “Cytokines in breast cancer,” Cytokine & Growth Factor Reviews, vol. 17, no. 5, pp. 325–337, 2006. View at Google Scholar
- F. Balkwill and A. Mantovani, “Inflammation and cancer: back to Virchow?” The Lancet, vol. 357, no. 9255, pp. 539–545, 2001. View at Publisher · View at Google Scholar · View at Scopus
- L. M. Coussens and Z. Werb, “Inflammation and cancer,” Nature, vol. 420, no. 6917, pp. 860–867, 2002. View at Publisher · View at Google Scholar · View at Scopus
- A. Ben-Baruch, “The multifaceted roles of chemokines in malignancy,” Cancer and Metastasis Reviews, vol. 25, no. 3, pp. 357–371, 2006. View at Publisher · View at Google Scholar · View at Scopus
- T. Boon and B. van den Eynde, “Tumour immunology,” Current Opinion in Immunology, vol. 15, no. 2, pp. 129–130, 2003. View at Publisher · View at Google Scholar · View at Scopus
- J. Wilson and F. Balkwill, “The role of cytokines in the epithelial cancer microenvironment,” Seminars in Cancer Biology, vol. 12, no. 2, pp. 113–120, 2002. View at Publisher · View at Google Scholar · View at Scopus
- C. H. Hsing, H. C. Cheng, Y. H. Hsu et al., “Upregulated IL-19 in breast cancer promotes tumor progression and affects clinical outcome,” Clinical Cancer Research, vol. 18, no. 3, pp. 713–725, 2012. View at Google Scholar
- W. E. Naugler and M. Karin, “The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer,” Trends in Molecular Medicine, vol. 14, no. 3, pp. 109–119, 2008. View at Publisher · View at Google Scholar · View at Scopus
- J. Massague, “TGFbeta in cancer,” Cell, vol. 134, no. 2, pp. 215–230, 2008. View at Google Scholar
- P. Romagnani, L. Lasagni, F. Annunziato, M. Serio, and S. Romagnani, “CXC chemokines: the regulatory link between inflammation and angiogenesis,” Trends in Immunology, vol. 25, no. 4, pp. 201–209, 2004. View at Publisher · View at Google Scholar · View at Scopus
- C. Chavey, F. Bibeau, S. Gourgou-Bourgade et al., “Oestrogen receptor negative breast cancers exhibit high cytokine content,” Breast Cancer Research, vol. 9, no. 1, article R15, 2007. View at Publisher · View at Google Scholar · View at Scopus
- S. U. Woo, J. W. Bae, J. H. Yang, J. H. Kim, S. J. Nam, and Y. K. Shin, “Overexpression of interleukin-10 in sentinel lymph node with breast cancer,” Annals of Surgical Oncology, vol. 14, no. 11, pp. 3268–3273, 2007. View at Publisher · View at Google Scholar · View at Scopus
- N. J. Sullivan, A. K. Sasser, A. E. Axel et al., “Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells,” Oncogene, vol. 28, no. 33, pp. 2940–2947, 2009. View at Publisher · View at Google Scholar · View at Scopus
- A. Purohit, S. P. Newman, and M. J. Reed, “The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer,” Breast Cancer Research, vol. 4, no. 2, pp. 65–69, 2002. View at Publisher · View at Google Scholar · View at Scopus
- M. E. E. Sabbioni, H. P. Siegrist, M. Bacchi et al., “Association between immunity and prognostic factors in early stage breast cancer patients before adjuvant treatment,” Breast Cancer Research and Treatment, vol. 59, no. 3, pp. 279–287, 2000. View at Publisher · View at Google Scholar · View at Scopus
- C. H. Hsing, H. H. Li, Y. H. Hsu et al., “The distribution of interleukin-19 in healthy and neoplastic tissue,” Cytokine, vol. 44, no. 2, pp. 221–228, 2008. View at Publisher · View at Google Scholar · View at Scopus
- S. Commins, J. W. Steinke, and L. Borish, “The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29,” Journal of Allergy and Clinical Immunology, vol. 121, no. 5, pp. 1108–1111, 2008. View at Publisher · View at Google Scholar · View at Scopus
- G. Gallagher, “Interleukin-19: multiple roles in immune regulation and disease,” Cytokine and Growth Factor Reviews, vol. 21, no. 5, pp. 345–352, 2010. View at Publisher · View at Google Scholar · View at Scopus
- K. Wolk, S. Kunz, K. Asadullah, and R. Sabat, “Cutting edge: immune cells as sources and targets of the IL-10 family members?” Journal of Immunology, vol. 168, no. 11, pp. 5397–5402, 2002. View at Google Scholar · View at Scopus
- W. Ouyang, S. Rutz, N. K. Crellin et al., “Regulation and functions of the IL-10 family of cytokines in inflammation and disease,” Annual Review of Immunology, vol. 29, pp. 71–109, 2011. View at Google Scholar
- H. Fickenscher, S. Hör, H. Küpers, A. Knappe, S. Wittmann, and H. Sticht, “The interleukin-10 family of cytokines,” Trends in Immunology, vol. 23, no. 2, pp. 89–96, 2002. View at Publisher · View at Google Scholar · View at Scopus
- L. Dumoutier, C. Leemans, D. Lejeune, S. V. Kotenko, and J. C. Renauld, “Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types,” Journal of Immunology, vol. 167, no. 7, pp. 3545–3549, 2001. View at Google Scholar · View at Scopus
- A. Zdanov, “Structural features of the interleukin-10 family of cytokines,” Current Pharmaceutical Design, vol. 10, no. 31, pp. 3873–3884, 2004. View at Publisher · View at Google Scholar · View at Scopus
- C. Chang, E. Magracheva, S. Kozlov et al., “Crystal structure of interleukin-19 defines a new subfamily of helical cytokines,” Journal of Biological Chemistry, vol. 278, no. 5, pp. 3308–3313, 2003. View at Publisher · View at Google Scholar · View at Scopus
- P. Conti, D. Kempuraj, S. Frydas et al., “IL-10 subfamily members: IL-19, IL-20, IL-22, IL-24 and IL-26,” Immunology Letters, vol. 88, no. 3, pp. 171–174, 2003. View at Publisher · View at Google Scholar · View at Scopus
- S. Pestka, C. D. Krause, D. Sarkar, M. R. Walter, Y. Shi, and P. B. Fisher, “Interleukin-10 and related cytokines and receptors,” Annual Review of Immunology, vol. 22, pp. 929–979, 2004. View at Publisher · View at Google Scholar · View at Scopus
- J. A. Langer, E. C. Cutrone, and S. Kotenko, “The Class II cytokine receptor (CRF2) family: overview and patterns of receptor-ligand interactions,” Cytokine and Growth Factor Reviews, vol. 15, no. 1, pp. 33–48, 2004. View at Publisher · View at Google Scholar · View at Scopus
- S. V. Kotenko, “The family of IL-10-related cytokines and their receptors: related, but to what extent?” Cytokine and Growth Factor Reviews, vol. 13, no. 3, pp. 223–240, 2002. View at Publisher · View at Google Scholar · View at Scopus
- G. Gallagher, H. Dickensheets, J. Eskdale et al., “Cloning, expression and initial characterisation of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10),” Genes and Immunity, vol. 1, no. 7, pp. 442–450, 2000. View at Google Scholar · View at Scopus
- C. H. Hsing, M. Y. Hsieh, W. Y. Chen, E. Cheung So, B. C. Cheng, and M. S. Chang, “Induction of interleukin-19 and interleukin-22 after cardiac surgery with cardiopulmonary bypass,” Annals of Thoracic Surgery, vol. 81, no. 6, pp. 2196–2201, 2006. View at Publisher · View at Google Scholar · View at Scopus
- Y. C. Liao, W. G. Liang, F. W. Chen, J. H. Hsu, J. J. Yang, and M. S. Chang, “IL-19 induces production of IL-6 and TNF-α and results in cell apoptosis through TNF-α,” Journal of Immunology, vol. 169, no. 8, pp. 4288–4297, 2002. View at Google Scholar · View at Scopus
- S. C. Liao, Y. C. Cheng, Y. C. Wang et al., “IL-19 induced Th2 cytokines and was up-regulated in asthma patients,” Journal of Immunology, vol. 173, no. 11, pp. 6712–6718, 2004. View at Google Scholar · View at Scopus
- S. Pletnev, E. Magracheva, S. Kozlov et al., “Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20,” Biochemistry, vol. 42, no. 43, pp. 12617–12624, 2003. View at Publisher · View at Google Scholar · View at Scopus
- D. Preimel and H. Sticht, “Molecular modeling of the interleukin-19 receptor complex. Novel aspects of receptor recognition in the interleukin-10 cytokine family,” Journal of Molecular Modeling, vol. 10, no. 4, pp. 290–296, 2004. View at Publisher · View at Google Scholar · View at Scopus
- J. Parrish-Novak, W. Xu, T. Brender et al., “Interleukins 19, 20, and 24 signal through two distinct receptor complexes: differences in receptor-ligand interactions mediate unique biological functions,” Journal of Biological Chemistry, vol. 277, no. 49, pp. 47517–47523, 2002. View at Publisher · View at Google Scholar · View at Scopus
- R. Menon, L. Ismail, D. Ismail, M. Merialdi, S. J. Lombardi, and S. J. Fortunato, “Human fetal membrane expression of IL-19 and IL-20 and its differential effect on inflammatory cytokine production,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 19, no. 4, pp. 209–214, 2006. View at Publisher · View at Google Scholar · View at Scopus
- Y. T. Azuma, Y. Matsuo, M. Kuwamura et al., “Interleukin-19 protects mice from innate-mediated colonic inflammation,” Inflammatory Bowel Diseases, vol. 16, no. 6, pp. 1017–1028, 2010. View at Publisher · View at Google Scholar · View at Scopus
- A. A. Cuneo, D. Herrick, and M. V. Autieri, “Il-19 reduces VSMC activation by regulation of mRNA regulatory factor HuR and reduction of mRNA stability,” Journal of Molecular and Cellular Cardiology, vol. 49, no. 4, pp. 647–654, 2010. View at Publisher · View at Google Scholar · View at Scopus
- C. H. Yeh, B. C. Cheng, C. C. Hsu et al., “Induced interleukin-19 contributes to cell-mediated immunosuppression in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass,” Annals of Thoracic Surgery, vol. 92, no. 4, pp. 1252–1259, 2011. View at Google Scholar
- C. H. Hsing, C. J. Chiu, L. Y. Chang, C. C. Hsu, and M. S. Chang, “IL-19 is involved in the pathogenesis of endotoxic shock,” Shock, vol. 29, no. 1, pp. 7–15, 2008. View at Publisher · View at Google Scholar · View at Scopus
- C. H. Hsing, C. C. Hsu, W. Y. Chen, L. Y. Chang, J. C. Hwang, and M. S. Chang, “Expression of IL-19 correlates with Th2 cytokines in uraemic patients,” Nephrology Dialysis Transplantation, vol. 22, no. 8, pp. 2230–2238, 2007. View at Publisher · View at Google Scholar · View at Scopus
- H. H. Li, Y. C. Lin, P. J. Chen et al., “Interleukin-19 upregulates keratinocyte growth factor and is associated with psoriasis,” British Journal of Dermatology, vol. 153, no. 3, pp. 591–595, 2005. View at Publisher · View at Google Scholar · View at Scopus
- N. Sakurai, T. Kuroiwa, H. Ikeuchi et al., “Expression of IL-19 and its receptors in RA: potential role for synovial hyperplasia formation,” Rheumatology, vol. 47, no. 6, pp. 815–820, 2008. View at Publisher · View at Google Scholar · View at Scopus
- K. Gabunia, S. P. Ellison, H. Singh et al., “Interleukin-19 (IL-19) induces heme oxygenase-1 (HO-1) expression and decreases reactive oxygen species in human vascular smooth muscle cells,” Journal of Biological Chemistry, vol. 287, no. 4, pp. 2477–2484, 2012. View at Google Scholar
- L. Huang, H. C. Cheng, R. Isom, C. S. Chen, R. A. Levine, and B. U. Pauli, “Protein kinase Cε mediates polymeric fibronectin assembly on the surface of blood-borne rat breast cancer cells to promote pulmonary metastasis,” Journal of Biological Chemistry, vol. 283, no. 12, pp. 7616–7627, 2008. View at Publisher · View at Google Scholar · View at Scopus
- N. Chaudarya and R. P. Hill, “Hypoxia and metastasis in breast cancer,” Breast Disease, vol. 26, no. 1, pp. 55–64, 2006. View at Google Scholar · View at Scopus
- D. Generali, A. Berruti, M. P. Brizzi et al., “Hypoxia-inducible factor-1α expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer,” Clinical Cancer Research, vol. 12, no. 15, pp. 4562–4568, 2006. View at Publisher · View at Google Scholar · View at Scopus
- Y. M. Li, Y. Pan, Y. Wei et al., “Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis,” Cancer Cell, vol. 6, no. 5, pp. 459–469, 2004. View at Publisher · View at Google Scholar · View at Scopus
- R. Paduch, A. Walter-Croneck, B. Zdzisińska, A. Szuster-Ciesielska, and M. Kandefer-Szerszeń, “Role of reactive oxygen species (ROS), metalloproteinase-2 (MMP-2) and interleukin-6 (IL-6) in direct interactions between tumour cell spheroids and endothelial cell monolayer,” Cell Biology International, vol. 29, no. 7, pp. 497–505, 2005. View at Publisher · View at Google Scholar · View at Scopus
- R. C. Johnson, D. Zhu, H. G. Augustin-Voss, and B. U. Pauli, “Lung endothelial dipeptidyl peptidase IV is an adhesion molecule for lung- metastatic rat breast and prostate carcinoma cells,” Journal of Cell Biology, vol. 121, no. 6, pp. 1423–1432, 1993. View at Google Scholar · View at Scopus
- M. Stein, S. Keshav, N. Harris, and S. Gordon, “Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation,” Journal of Experimental Medicine, vol. 176, no. 1, pp. 287–292, 1992. View at Publisher · View at Google Scholar · View at Scopus
- J. E. Maglione, D. Moghanaki, L. J. T. Young et al., “Transgenic Polyoma middle-T mice model premalignant mammary disease,” Cancer Research, vol. 61, no. 22, pp. 8298–8305, 2001. View at Google Scholar · View at Scopus
- H. Maeda, H. Kuwahara, Y. Ichimura, M. Ohtsuki, S. Kurakata, and A. Shiraishi, “TGF-β enhances macrophage ability to produce IL-10 in normal and tumor- bearing mice,” Journal of Immunology, vol. 155, no. 10, pp. 4926–4932, 1995. View at Google Scholar · View at Scopus
- F. Balkwill, K. A. Charles, and A. Mantovani, “Smoldering and polarized inflammation in the initiation and promotion of malignant disease,” Cancer Cell, vol. 7, no. 3, pp. 211–217, 2005. View at Publisher · View at Google Scholar · View at Scopus
- K. Watanabe, P. J. Jose, and S. M. Rankin, “Eotaxin-2 generation is differentially regulated by lipopolysaccharide and IL-4 in monocytes and macrophages,” Journal of Immunology, vol. 168, no. 4, pp. 1911–1918, 2002. View at Google Scholar · View at Scopus
- S. K. Bunt, L. Yang, P. Sinha, V. K. Clements, J. Leips, and S. Ostrand-Rosenberg, “Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression,” Cancer Research, vol. 67, no. 20, pp. 10019–10026, 2007. View at Publisher · View at Google Scholar · View at Scopus
- G. Gallagher, J. Eskdale, W. Jordan et al., “Human interleukin-19 and its receptor: a potential role in the induction of Th2 responses,” International Immunopharmacology, vol. 4, no. 5, pp. 615–626, 2004. View at Publisher · View at Google Scholar · View at Scopus
- J. A. Lederer, M. L. Rodrick, and J. A. Mannick, “The effects of injury on the adaptive immune response,” Shock, vol. 11, no. 3, pp. 153–159, 1999. View at Google Scholar · View at Scopus
- S. T. O'Sullivan, J. A. Lederer, A. F. Horgan et al., “Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection,” Annals of Surgery, vol. 222, no. 4, pp. 482–492, 1995. View at Google Scholar · View at Scopus