Sphingolipids and Brain Resident Macrophages in Neuroinflammation: An Emerging Aspect of Nervous System Pathology

Figure 1

Schematic representation of main sphingolipid metabolic pathway. SM: sphingomyelin; Cer: ceramide; A-SMase: acid sphingomyelinase; N-SMase: neutral sphingomyelinase; A-CDase: acid ceramidase; N-CDase: neutral ceramidase; SMS: sphingomyelin synthase; Sph: sphingosine; S1P: sphingosine-1-phosphate; SK: sphingosine kinase; dhCer: dihydroceramide; CerS: ceramide synthase; GluCer: glucosylceramide; GCS: glucosylceramide synthase; GT: glycosyltransferase; GSL: ganglioside; Ser: serine.