Immunomodulatory Effect of Bisphosphonate Risedronate Sodium on CD163⁺ Arginase 1⁺ M2 Macrophages: The Development of a Possible Supportive Therapy for Angiosarcoma

Figure 3

DTX with or without RS effects on the production of CXCL10, CXCL11, CCL17, CCL18, CCL22, and IL-10. The culture supernatants of M2 macrophages stimulated with DTX and/or RS were collected at 48 h after culture. Their chemokine and cytokine production was measured by ELISA. Representative data from at least three independent experiments are shown.

(a)

(b)

(c)

(d)

(e)

(f)

(g)