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Clinical and Developmental Immunology
Volume 2013, Article ID 345347, 7 pages
http://dx.doi.org/10.1155/2013/345347
Research Article

Correlation between the Frequency of Th17 Cell and the Expression of MicroRNA-206 in Patients with Dermatomyositis

1Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University School of Medical Science and Laboratory Medicine, Zhenjiang 212013, China
2Department of Pathology and Centre of Infection and Immunology, The University of Hong Kong, Hong Kong
3Institute of Laboratory Medicine, Jiangsu University, Zhenjiang, China

Received 1 August 2013; Revised 11 September 2013; Accepted 13 September 2013

Academic Editor: E. Shevach

Copyright © 2013 Xinyi Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

It was reported that IL-17 had been detected in the inflammatory infiltrates of patients with DM (dermatomyositis). In this study, we investigated the frequency of Th17 cells and the expression of microRNA-206 (miR-206) in DM patients. Firstly, we observed that the frequency of Th17 cells and the expression of transcription factors were increased significantly in the PBMCs of DM patients. Secondly, we found that there was a positive correlation between the percentages of Th17 cells and serum level of CK in DM patients. And the serum concentrations of IL-6, IL-1β, TGF-β, and IL-23, the important cytokines of Th17 differentiation, were increased in DM patients. It was predicted that Krüppel-like factor 4 (KLF4) is one of the multiple targets of miR-206. We detected the expression of miR-206 in DM patients, and it was decreased in the serum and PBMCs of DM patients. The augmented expression of KLF is accompanied by the attenuated expression of miR-206. Furthermore, a negative correlation between the percentages of Th17 cells and the expression of miR-206 in DM patients has been found. Taken together, these findings suggest the attenuated expression of miR-206, and the augmented frequency of Th17 cells in DM patients.