Journal of Immunology Research / 2013 / Article / Tab 1 / Research Article
Clinical Factors Influencing Phenotype of HCMV-Specific CD8+ T Cells and HCMV-Induced Interferon-Gamma Production after Allogeneic Stem Cells Transplantation Table 1 Clinical characteristics of the study population.
Characteristics Data Patients (number) 26 Recipient age (years): mean (SD) 40 (13.5) Donor age (years): mean (SD) 40 (15) Recipient sex, male/female, (
, (%)) 15 (57.7)/11 (42.3) Donor sex, male/female (
, (%)) 20 (76.9)/6 (23.1) Disease (
, (%)) AML 5 (19.2) ALL 2 (7.6) CML 3 (11.5) Non-Hodgkin’s lymphoma 4 (15.3) MM 4 (15.3) Aplasia 2 (7.6) MDS 3 (11.5) PNH 3 (11.5) Conditioning regimen (
, (%)) NMA 13 (50) MA 13 (50) Stem cell source (
, (%)) Bone marrow 12 (46.1) Peripheral blood 14 (53.8) Pretransplant HCMV donor serostatus/recipient (
, (%)) D+/R+ 14 (53.8) D−/R+ 10 (38.4) D−/R− 2 (7.7) HCMV replication after transplant (
, (%)) Yes 15 (57.7) No 11 (42.3) HLA matching (
, (%)) Matched related 18 (69.2) Matched unrelated 6 (23.1) Mismatched unrelated 2 (7.7) GVHD (
, (%)) Yes 11 (42.3) No 15 (57.7) Corticosteroids (
, (%)) Yes 18 (69.2) No 8 (30.8) Frequency of CD8+ T cells (mean, SD) 35.1 (14.8) Frequency of HCMV-specific CD8+ T cells (mean, SD) 1.4 (2.1) Frequency of HCMV-specific CD8+ T cells naive (mean, SD) 6.7 (11.3) Frequency of HCMV-specific CD8+ T cells CD28+ (mean, SD) 30 (23.2)
AML: acute myeloid leukemia; ALL: acute lymphatic leukemia; CML: chronic myeloid leukemia; MM: multiple myeloma; MDS: myelodysplastic syndrome; PNH: paroxysmal nocturnal hemoglobinuria; NMA: non-myeloablative; MA: myeloablative. D: donor; R: recipient; HCMV: human cytomegalovirus; GVHD: graft-versus-host disease. Naive cells are CD45RA+CCR7+.