Table of Contents Author Guidelines Submit a Manuscript
Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 362163, 9 pages
http://dx.doi.org/10.1155/2013/362163
Research Article

Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells

1EM-Silicon Nano-Technologies SL, Nat. R. Cisternas 8, 46010 Valencia, Spain
2Immunology Department, Faculty of Medicine, Complutense University, Avenida Complutense s/n, 28040 Madrid, Spain
3Cell Biology Department, Faculty of Medicine, Complutense University, Avenida Complutense s/n, 28040 Madrid, Spain

Received 25 June 2013; Accepted 15 September 2013

Academic Editor: Masha Fridkis-Hareli

Copyright © 2013 A. Jiménez-Periáñez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The mesoporous silicon microparticles (MSMPs) are excellent vehicles for releasing molecules inside the cell. The aim of this work was to use MSMPs to deliver viral specific MHC class I restricted epitopes into human antigen presenting cells (monocyte derived dendritic cells, MDDCs) to facilitate their capture, processing, and presentation to CD8+ (cytotoxic) T lymphocytes. We show for the first time that MSMPs vehiculation of antigenic peptides enhances their MHC class I presentation by human MDDCs to CD8 T lymphocytes.