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Clinical and Developmental Immunology
Volume 2013, Article ID 410521, 5 pages
Clinical Study

Long-Term Safety of Anti-TNF Adalimumab in HBc Antibody-Positive Psoriatic Arthritis Patients: A Retrospective Case Series of 8 Patients

1Unità di Reumatologia, Istituto Dermopatico dell’Immacolata-IRCCS, Via Monti di Creta 104, 00165 Rome, Italy
2Unità di Reumatologia, Ospedale S. Pietro Fatebenefratelli, Via Cassia 600, 00189 Rome, Italy
3Unità di Dermatologia, Istituto Dermopatico dell’Immacolata-IRCCS, Via Monti di Creta 104, 00165 Rome, Italy
4Unità di Gastroenterologia, Ospedale San Carlo, Via Aurelia 275, 00165 Rome, Italy

Received 16 October 2012; Revised 12 February 2013; Accepted 18 February 2013

Academic Editor: Tae-Hwan Kim

Copyright © 2013 R. Laurenti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Immunosuppressive drugs commonly used in the treatment of psoriatic arthritis make patients more susceptible to viral, bacterial, and fungal infections because of their mechanism of action. They not only increase the risk of new infections but also act altering the natural course of preexisting infections. While numerous data regarding the reactivation of tuberculosis infection are available in the literature, poor information about the risk of reactivation or exacerbation of hepatitis viruses B and C infections during treatment with biologics has been reported. Furthermore, reported series with biological therapy included short periods of followup, and therefore, they are not adequate to verify the risk of reactivation in the long-term treatment. Our study evaluated patients with a history of hepatitis B and psoriatic arthritis treated with adalimumab and monitored up to six years. During the observation period, treatment was effective and well tolerated in all patients, and liver function tests and viral load levels remained unchanged.