Research Article
The Diagnostic Value of Transcription Factors T-bet/GATA3 Ratio in Predicting Antibody-Mediated Rejection
Table 2
Patients’ demography and histologic characters with different T-bet/GATA3 ratios and status of C4d deposition.
| | T-bet/GATA3>1 () | T-bet/GATA3≤1 () | | C4d+ () | C4d− () | |
| Gender (female %) | 8 (53.3%) | 3 (27.3%) | 0.193 | 9 (81.8%) | 2 (13.3) | <0.001 | Age | | | 0.938 | | | 0.790 | Rejection type | | | | | | | ABMR | 14 (93.3%) | 2 (18.2%) | <0.001 | 11 (100%) | 5 (33.3%) | 0.001 | TCMR | 1 (6.7%) | 9 (81.8%) | <0.001 | 0 | 10 (66.7%) | 0.001 | Positive HLA-I or II Ab | 14 (93.3%) | 2 (18.2%) | <0.001 | 11 (100%) | 5 (33.3%) | <0.001 | Histological features | | | | | | | Peritubular capillaritis | 14 (93.3%) | 7 (63.6%) | 0.163 | 11 (100%) | 10 (66.7%) | 0.037 | PTC score | | | 0.052 | | | 0.094 | Glomerulitis | 15 (100%) | 7 (63.6%) | 0.013 | 11 (100%) | 11 (73.3%) | 0.068 | Glomerulitis score | | | <0.001 | | | 0.013 | Tubulitis | 12 (80.0%) | 11 (100%) | 0.339 | 8 (72.7%) | 14 (93.3%) | 0.158 | Tubulitis score | | | 0.106 | | | 0.047 | Intraglomerular CD68 | | | 0.006 | | | 0.059 | Intraglomerular T-bet | | | 0.007 | | | 0.077 | Intraglomerular GATA3 | | | 0.001 | | | 0.034 |
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ABMR: antibody-mediated rejection; TCMR, T-cell-mediated rejection.
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