Journal of Immunology Research / 2013 / Article / Tab 2

Research Article

The Diagnostic Value of Transcription Factors T-bet/GATA3 Ratio in Predicting Antibody-Mediated Rejection

Table 2

Patients’ demography and histologic characters with different T-bet/GATA3 ratios and status of C4d deposition.

T-bet/GATA3>1
( )
T-bet/GATA3≤1
( )
C4d+
( )
C4d−
( )

Gender (female %)8 (53.3%)3 (27.3%)0.1939 (81.8%)2 (13.3)<0.001
Age 0.938 0.790
Rejection type
 ABMR 14 (93.3%)2 (18.2%)<0.00111 (100%)5 (33.3%)0.001
 TCMR 1 (6.7%)9 (81.8%)<0.001010 (66.7%)0.001
Positive HLA-I or II Ab 14 (93.3%)2 (18.2%)<0.00111 (100%)5 (33.3%)<0.001
Histological features
 Peritubular capillaritis14 (93.3%)7 (63.6%)0.16311 (100%)10 (66.7%)0.037
 PTC score 0.052 0.094
 Glomerulitis15 (100%)7 (63.6%)0.01311 (100%)11 (73.3%)0.068
 Glomerulitis score <0.001 0.013
 Tubulitis12 (80.0%)11 (100%)0.3398 (72.7%)14 (93.3%)0.158
 Tubulitis score 0.106 0.047
Intraglomerular CD68 0.006 0.059
Intraglomerular T-bet 0.007 0.077
Intraglomerular GATA3 0.001 0.034

ABMR: antibody-mediated rejection; TCMR, T-cell-mediated rejection.

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