The Diagnostic Value of Transcription Factors T-bet/GATA3 Ratio in Predicting Antibody-Mediated Rejection

Table 2

Patients’ demography and histologic characters with different T-bet/GATA3 ratios and status of C4d deposition.

	T-bet/GATA3>1; (𝑛=15)	T-bet/GATA3≤1; (𝑛=11)	𝑃	C4d+; (𝑛=11)	C4d−; (𝑛=15)	𝑃
Gender (female %)	8 (53.3%)	3 (27.3%)	0.193	9 (81.8%)	2 (13.3)	<0.001
Age	39.40±8.72	39.73±12.48	0.938	40.18±8.38	39.07±11.69	0.790
Rejection type
ABMR	14 (93.3%)	2 (18.2%)	<0.001	11 (100%)	5 (33.3%)	0.001
TCMR	1 (6.7%)	9 (81.8%)	<0.001	0	10 (66.7%)	0.001
Positive HLA-I or II Ab	14 (93.3%)	2 (18.2%)	<0.001	11 (100%)	5 (33.3%)	<0.001
Histological features
Peritubular capillaritis	14 (93.3%)	7 (63.6%)	0.163	11 (100%)	10 (66.7%)	0.037
PTC score	1.93±1.03	1.09±1.04	0.052	2.00±0.89	1.27±1.16	0.094
Glomerulitis	15 (100%)	7 (63.6%)	0.013	11 (100%)	11 (73.3%)	0.068
Glomerulitis score	2.20±0.94	0.73±0.65	<0.001	2.18±0.98	1.13±0.99	0.013
Tubulitis	12 (80.0%)	11 (100%)	0.339	8 (72.7%)	14 (93.3%)	0.158
Tubulitis score	1.07±0.80	1.64±0.92	0.106	0.91±0.70	1.60±0.91	0.047
Intraglomerular CD68	9.03±7.86	1.89±4.09	0.006	9.49±8.79	3.45±5.01	0.059
Intraglomerular T-bet	2.66±2.74	0.42±0.48	0.007	2.67±3.20	1.02±1.18	0.077
Intraglomerular GATA3	0.69±0.61	2.20±1.41	0.001	0.73±0.71	1.77±1.41	0.034

ABMR: antibody-mediated rejection; TCMR, T-cell-mediated rejection.