The Diagnostic Value of Transcription Factors T-bet/GATA3 Ratio in Predicting Antibody-Mediated Rejection

Table 3

Histologic lesion of renal allograft.

	C4d(+) ABMR; (𝑛=11)	C4d(−) ABMR; (𝑛=5)	TCMR; (𝑛=10)	𝑃12	𝑃13	𝑃23
PTC inflammation, 𝑛 (%)	11 (100%)	5 (100%)	4 (40%)	—	0.003	0.031
PTC score	2±0.89	2.20±1.10	0.80±0.92	0.704	0.007	0.021
Glomerulitis, 𝑛 (%)	11 (100%)	5 (100%)	6 (60%)	—	0.023	0.111
Glomerulitis score	2.18±0.98	2.00±1.00	0.70±0.67	0.738	0.001	0.010
Tubulitis, 𝑛 (%)	8 (72.7%)	4 (80%)	10 (100%)	0.763	0.082	0.157
Tubulitis score	0.91±0.70	0.80±0.45	2.00±0.82	0.756	0.004	0.010
Intimal arteritis, 𝑛 (%)	7 (63.6%)	3 (60%)	3 (30%)	0.893	0.133	0.280
Interstitial inflammation score	1.73±0.65	2.4±0.55	1.7±0.67	0.064	0.926	0.067
Intraglomerular immunohistological analysis
T-bet (cells/glomeruli)	2.67±3.20	2.30±1.19	0.37±0.42	0.808	0.039	0.020
GATA3 (cells/glomeruli)	0.73±0.71	1.32±0.78	2.00±1.63	0.156	0.042	0.401
T-bet/GATA3>1	9 (81.8%)	4 (80%)	1 (10%)	0.933	0.001	0.009
Interstitial immunohistological analysis
T-bet (cells/mm^2)	63.64±65.88	77.6±47.72	124.40±112.66	0.679	0.158	0.280
GATA3 (cells/mm^2)	20±37.65	11.2±20.86	27.2±41.17	0.636	0.680	0.434
T-bet/GATA3>1	9 (81.8%)	5 (100%)	9 (90%)	0.324	0.602	0.480

ABMR: antibody-mediated rejection; TCMR, T-cell-mediated rejection.
𝑃12 means 𝑃 value for C4d(+) ABMR group and C4d(−) ABMR group, 𝑃13 means 𝑃 value for C4d(+) ABMR group and TCMR group, 𝑃23 means 𝑃 value for C4d(−) ABMR group and TCMR group.