Table of Contents Author Guidelines Submit a Manuscript
Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 467852, 7 pages
http://dx.doi.org/10.1155/2013/467852
Review Article

Evaluating the Immunogenicity of Protein Drugs by Applying In Vitro MHC Binding Data and the Immune Epitope Database and Analysis Resource

La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, San Diego, CA 92037, USA

Received 6 May 2013; Accepted 3 September 2013

Academic Editor: Pedro A. Reche

Copyright © 2013 Sinu Paul et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [20 citations]

The following is the list of published articles that have cited the current article.

  • Hiroki Shirai, Catherine Prades, Randi Vita, Paolo Marcatili, Bojana Popovic, Jianqing Xu, John P. Overington, Kazunori Hirayama, Shinji Soga, Kazuhisa Tsunoyama, Dominic Clark, Marie-Paule Lefranc, and Kazuyoshi Ikeda, “Antibody Informatics for Drug Discovery,” Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2014. View at Publisher · View at Google Scholar
  • Ken T. Coppieters, and Matthias G. von Herrath, “Metabolic syndrome – Removing roadblocks to therapy: Antigenic immunotherapies,” Molecular Metabolism, 2014. View at Publisher · View at Google Scholar
  • Heng Luo, Hao Ye, Hui Wen Ng, Leming Shi, Weida Tong, William Mattes, Donna Mendrick, and Huixiao Hong, “Understanding and predicting binding between human leukocyte antigens (HLAs) and peptides by network analysis,” Bmc Bioinformatics, vol. 16, 2015. View at Publisher · View at Google Scholar
  • Ronit Mazor, Chin-Hsien Tai, Byungkook Lee, and Ira Pastan, “Poor correlation between T-cell activation assays and HLA-DR binding prediction algorithms in an immunogenic fragment of Pseudomonas exotoxin A,” Journal of Immunological Methods, 2015. View at Publisher · View at Google Scholar
  • Shusheng Geng, Hong Chang, Weisong Qin, Ming Lv, Yan Li, Jiannan Feng, and Beifen Shen, “A novel anti-TNF scFv constructed with human antibody frameworks and antagonistic peptides,” Immunologic Research, 2015. View at Publisher · View at Google Scholar
  • Sinu Paul, Myles B. C. Dillon, Cecilia S. Lindestam Arlehamn, Huang Huang, Mark M. Davis, Denise M. McKinney, Thomas Jens Scriba, John Sidney, Bjoern Peters, and Alessandro Sette, “A Population Response Analysis Approach To Assign Class II HLA-Epitope Restrictions,” Journal Of Immunology, vol. 194, no. 12, pp. 6164–6176, 2015. View at Publisher · View at Google Scholar
  • Sinu Paul, Cecilia S. Lindestam Arlehamn, Thomas J. Scriba, Myles B.C. Dillon, Carla Oseroff, Denise Hinz, Denise M. McKinney, Sebastian Carrasco Pro, John Sidney, Bjoern Peters, and Alessandro Sette, “Development and validation of a broad scheme for prediction of HLA class II restricted T cell epitopes,” Journal of Immunological Methods, 2015. View at Publisher · View at Google Scholar
  • Jane C. Burns, Ranim Touma, Yali Song, Robert L. Padilla, Adriana H. Tremoulet, John Sidney, Alessandro Sette, and Alessandra Franco, “Fine specificities of natural regulatory T cells after IVIG therapy in patients with Kawasaki disease,” Autoimmunity, pp. 1–8, 2015. View at Publisher · View at Google Scholar
  • Regina S. Salvat, Yoonjoo Choi, Alexandra Bishop, Chris Bailey-Kellogg, and Karl E. Griswold, “Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads,” Biotechnology and Bioengineering, 2015. View at Publisher · View at Google Scholar
  • Kathleen P. Pratt, “Engineering less Immunogenic and Antigenic FVIII Proteins,” Cellular Immunology, 2015. View at Publisher · View at Google Scholar
  • Heng Luo, Hao Ye, Hui Wen Ng, Leming Shi, Weida Tong, Donna L. Mendrick, and Huixiao Hong, “Machine learning methods for predicting HLA–peptide binding activity,” Bioinformatics and Biology Insights, vol. 9, pp. 21–29, 2015. View at Publisher · View at Google Scholar
  • Regina S. Salvat, Andrew S. Parker, Yoonjoo Choi, Chris Bailey-Kellogg, and Karl E. Griswold, “Mapping the Pareto Optimal Design Space for a Functionally Deimmunized Biotherapeutic Candidate,” Plos Computational Biology, vol. 11, no. 1, 2015. View at Publisher · View at Google Scholar
  • Mqondisi Tshabalala, Juanita Mellet, and Michael S. Pepper, “Human Leukocyte Antigen Diversity: A Southern African Perspective,” Journal of Immunology Research, vol. 2015, pp. 1–11, 2015. View at Publisher · View at Google Scholar
  • Karl E Griswold, and Chris Bailey-Kellogg, “Design and engineering of deimmunized biotherapeutics,” Current Opinion in Structural Biology, vol. 39, pp. 79–88, 2016. View at Publisher · View at Google Scholar
  • Dina A. Salem, Yasser M. Kadah, and Rania A. Abul Seoud, “Robust Classification of Major Histocompatibility Complex Class II Peptides,” Journal of Medical Imaging and Health Informatics, vol. 6, no. 3, pp. 598–608, 2016. View at Publisher · View at Google Scholar
  • Rui-Xue Ma, Fang Wang, Xing-An Wu, Rong-Rong Liu, Tie-Jun Ma, Zi-Yu Liu, Wei Ye, Fang-Lin Zhang, Zhi-Kai Xu, Lin-Feng Cheng, Qi-Kang Ying, Xiao-Xiao Zhang, and Liang Zhang, “Screening and identification of an H-2Kb-restricted CTL epitope within the glycoprotein of Hantaan virus,” Frontiers in Cellular and Infection Microbiology, vol. 6, 2016. View at Publisher · View at Google Scholar
  • Moustafa Hamze, Sylvain Meunier, Anette Karle, Abdelaziz Gdoura, Amélie Goudet, Natacha Szely, Marc Pallardy, Franck Carbonnel, Sebastian Spindeldreher, Xavier Mariette, Corinne Miceli-Richard, and Bernard Maillère, “Characterization of CD4 T Cell Epitopes of Infliximab and Rituximab Identified from Healthy Donors,” Frontiers in Immunology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Ward Fleri, Sinu Paul, Sandeep Kumar Dhanda, Swapnil Mahajan, Xiaojun Xu, Bjoern Peters, and Alessandro Sette, “The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design,” Frontiers in Immunology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Marek Wieczorek, Esam T. Abualrous, Jana Sticht, Miguel Álvaro-Benito, Sebastian Stolzenberg, Frank Noé, and Christian Freund, “Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation,” Frontiers in Immunology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Ricardo da Silva Antunes, Sinu Paul, John Sidney, Daniela Weiskopf, Jennifer M. Dan, Elizabeth Phillips, Simon Mallal, Shane Crotty, Alessandro Sette, and Cecilia S. Lindestam Arlehamn, “Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4+ T Cell Responses,” Plos One, vol. 12, no. 1, pp. e0169086, 2017. View at Publisher · View at Google Scholar