Figure 1: Immunologic assessment before and after the rapamycin or cyclosporine treatment. (a) The Treg cells levels by the flow cytometry. Patients with CR and PR in the experimental group experienced a marked upregulation (CR group: % versus %, ; PR group: % versus 6. %, ); (b) the expression of Foxp3 mRNA by quantitative RT-PCR assay. It was consistent with the increase in Treg cells level (CR group: versus , ; PR group: versus , ); (c) the plasma levels of TGF-β by the enzyme-linked immunosorbent assay. A significant increase in the level of TGF-β was observed after the rapamycin treatment (CR group:  ng/mL versus  ng/mL, ; PR group:  ng/mL versus 2.  ng/mL, ).