Schematic illustration of Notch signaling pathway. Binding of the extracellular part of Notch receptor to ligands of the Delta and Jagged families induces proteolytic cleavage of Notch, releasing the intracellular part of the protein (NICD). NICD is then translocated to the nucleus and binds to the nuclear transcription factor RBP-Jκ inducing its conversion from a repressor into an activator to stimulate the transcription of Notch target genes.
