Persistent Suppression of Type 1 Diabetes by a Multicomponent Vaccine Containing a Cholera Toxin B Subunit-Autoantigen Fusion Protein and Complete Freund’s Adjuvant

Figure 3

Histological analysis of insulitis in mice at the end of the hyperglycemia study. Data on pancreatic tissue cross-sections of euglycemic mice of different treatment groups obtained from mice at 119 weeks of age are shown. Altogether, 13 mice (presented in the table below the graph) were analyzed and scored for insulitis: one mouse of the PBS control, rVV-CTB::GAD + CFA (1 : 100), and rVV-CTB::GAD treatment groups, five mice of the CFA (1 : 0), three mice of the rVV-CTB::GAD + CFA (1 : 10), and two mice of the rVV-CTB::GAD + CFA (1 : 0) groups. Blood glucose concentrations of individual (in mmol/L) or grouped (mean ± SD, in mmol/L) mice are also presented.