Persistent Suppression of Type 1 Diabetes by a Multicomponent Vaccine Containing a Cholera Toxin B Subunit-Autoantigen Fusion Protein and Complete Freund’s Adjuvant
Analyses of secreted cytokines/chemokines. (a) Cytokines/chemikines synthesized by splenocytes of CFA (1 : 0), rVV-CTB::GAD + CFA (1 : 0), and rVV-CTB::GAD + CFA (1 : 10) treatment group and naive (PBS) mice. (b) 4-5 mice from each experimental groups were euthanized and the synthesis of cytokines and chemokines in GAD-activated splenocytes was analysed. Means ± standard errors are shown for 4-5 mice/groups. Differences between ages of the treated groups of mice compared to PBS are statistically significant (one-way Anova, ). Differences between groups in blood glucose and data of percentage of insulitis are statistically insignificant (one-way Anova, ).
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