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Clinical and Developmental Immunology
Volume 2013, Article ID 586076, 10 pages
http://dx.doi.org/10.1155/2013/586076
Review Article

Neonatal Sepsis due to Coagulase-Negative Staphylococci

1Child and Family Research Institute, 4th Floor, Translational Research Building, 950 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4
2Department of Medicine, University of British Columbia, Vancouver, BC, Canada V6T 1ZA
3Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada V6T 1ZA
4Department of Pediatrics, Children’s Hospital, University of Oxford, Oxford OX3 9DU, UK

Received 12 March 2013; Revised 27 April 2013; Accepted 27 April 2013

Academic Editor: Robert Bortolussi

Copyright © 2013 Elizabeth A. Marchant et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Neonates, especially those born prematurely, are at high risk of morbidity and mortality from sepsis. Multiple factors, including prematurity, invasive life-saving medical interventions, and immaturity of the innate immune system, put these infants at greater risk of developing infection. Although advanced neonatal care enables us to save even the most preterm neonates, the very interventions sustaining those who are hospitalized concurrently expose them to serious infections due to common nosocomial pathogens, particularly coagulase-negative staphylococci bacteria (CoNS). Moreover, the health burden from infection in these infants remains unacceptably high despite continuing efforts. In this paper, we review the epidemiology, immunological risk factors, diagnosis, prevention, treatment, and outcomes of neonatal infection due to the predominant neonatal pathogen CoNS.