Journal of Immunology Research / 2013 / Article / Tab 2

Research Article

Overexpression of HIF-2α, TWIST, and CXCR4 Is Associated with Lymph Node Metastasis in Papillary Thyroid Carcinoma

Table 2

Immunohistochemical analysis of HIF-2 , TWIST, and CXCR4 expression in 129 PTCs, 61 nodular hyperplasia, and 118 normal thyroid tissue specimens according to the scoring system.

ScoreHIF-2αTWISTCXCR4
Normal thyroid tissue
(%)
Nodular hyperplasia
(%)
PTC
(%)
Normal thyroid tissue
(%)
Nodular hyperplasia
(%)
PTC
(%)
Normal thyroid tissue
(%)
Nodular hyperplasia
(%)
PTC
(%)

0
Negative94 (79.7)38 (62.3)4 (3.1)97 (82.2)40 (65.6)3 (2.3)91 (77.1)36 (59.0)3 (2.3)
+
 121 (17.8)18 (29.5)7 (5.4)19 (16.1)16 (26.2)12 (9.3)23 (19.5)19 (31.1)8 (6.2)
 23 (2.5)4 (6.6)16 (12.4)2 (1.7)5 (8.2)17 (13.2)4 (3.4)4 (6.6)13 (10.1)
 30 (0)1 (1.6)18 (14.0)0 (0)0 (0)19 (14.7)0 (0)2 (3.3)16 (12.4)
 40 (0)0 (0)20 (15.5)0 (0)0 (0)22 (17.1)0 (0)0 (0)18 (13.9)
++
 60 (0)0 (0)16 (12.4)0 (0)0 (0)19 (14.7)0 (0)0 (0)19 (14.7)
 80 (0)0 (0)23 (17.8)0 (0)0 (0)17 (13.2)0 (0)0 (0)17 (13.2)
+++
 90 (0)0 (0)16 (12.4)0 (0)0 (0)17 (13.2)0 (0)0 (0)20 (15.5)
 120 (0)0 (0)9 (7.0)0 (0)0 (0)3 (2.3)0 (0)0 (0)15 (11.6)

The immunohistochemical scores in PTCs, nodular hyperplasia, and normal thyroid tissue specimens were determined as the multiplication of proportion score and intensity score.

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