Overexpression of HIF-2α, TWIST, and CXCR4 Is Associated with Lymph Node Metastasis in Papillary Thyroid Carcinoma

Table 4

Correlation of HIF-2α, TWIST, and CXCR4 protein expression with one another in 129 PTCs.

Proteins	HIF-2α				CXCR4
	Low	High	𝑟𝑠	𝑃 value	Low	High	𝑟𝑠	𝑃 value
TWIST
Low	49	24	0.382	<0.001	46	27	0.414	<0.001
High	16	40			12	44
CXCR4
Low	42	16	0.398	<0.001
High	23	48

𝑃 values for Spearman rank test; HIF-2α, TWIST, and CXCR4 were tested pairwise; 𝑃<0.05 significant difference.