Overexpression of HIF-2α, TWIST, and CXCR4 Is Associated with Lymph Node Metastasis in Papillary Thyroid Carcinoma
Table 5
Correlation of concomitant expression of HIF-2α, TWIST, and CXCR4 with LNM.
LNM
Absent
Present
-value
HIF-2α/TWIST
<0.001a
(1) Both HIF-2α/TWIST low expression
43 (87.8)
6 (12.2)
(2) One of HIF-2α/TWIST high expression
13 (32.5)
27 (67.5)
0.032b
(3) Both HIF-2α/TWIST high expression
5 (12.5)
35 (87.5)
TWIST/CXCR4
<0.001a
(1) Both TWIST/CXCR4 low expression
41 (89.1)
5 (10.9)
(2) One of TWIST/CXCR4 high expression
14 (35.9)
25 (64.1)
0.018b
(3) Both TWIST/CXCR4 high expression
6 (13.6)
38 (86.4)
HIF-2α/CXCR4
<0.001a
(1) Both HIF-2α/CXCR4 low expression
38 (90.5)
4 (9.5)
(2) One of HIF-2α/CXCR4 high expression
18 (46.2)
21 (53.8)
<0.001b
(3) Both HIF-2α/CXCR4 high expression
5 (10.4)
43 (89.6)
HIF-2α/TWIST/CXCR4
Not all of HIF-2α/TWIST/CXCR4 high expression
58 (62.4)
35 (37.6)
<0.001c
All of HIF-2α/TWIST/CXCR4 high expression
3 (8.3)
33 (91.7)
Correlation of concomitant expression of HIF-2α, TWIST, and CXCR4 with LNM were measured by chi-square test; asignificant difference among the three groups; bsignificant difference between group (2) and group (3); csignificant difference between groups with and without concomitant expression of all three molecules.