Journal of Immunology Research / 2013 / Article / Tab 5

Research Article

Overexpression of HIF-2α, TWIST, and CXCR4 Is Associated with Lymph Node Metastasis in Papillary Thyroid Carcinoma

Table 5

Correlation of concomitant expression of HIF-2α, TWIST, and CXCR4 with LNM.

LNM
AbsentPresent -value

HIF-2α/TWIST<0.001a
(1) Both HIF-2α/TWIST low expression43 (87.8)6 (12.2)
(2) One of HIF-2α/TWIST high expression13 (32.5)27 (67.5)0.032b
(3) Both HIF-2α/TWIST high expression5 (12.5)35 (87.5)
TWIST/CXCR4<0.001a
(1) Both TWIST/CXCR4 low expression41 (89.1)5 (10.9)
(2) One of TWIST/CXCR4 high expression14 (35.9)25 (64.1)0.018b
(3) Both TWIST/CXCR4 high expression6 (13.6)38 (86.4)
HIF-2α/CXCR4<0.001a
(1) Both HIF-2α/CXCR4 low expression38 (90.5)4 (9.5)
(2) One of HIF-2α/CXCR4 high expression18 (46.2)21 (53.8)<0.001b
(3) Both HIF-2α/CXCR4 high expression5 (10.4)43 (89.6)
HIF-2α/TWIST/CXCR4
 Not all of HIF-2α/TWIST/CXCR4 high expression58 (62.4)35 (37.6)<0.001c
 All of HIF-2α/TWIST/CXCR4 high expression3 (8.3)33 (91.7)

Correlation of concomitant expression of HIF-2α, TWIST, and CXCR4 with LNM were measured by chi-square test; asignificant difference among the three groups; bsignificant difference between group (2) and group (3); csignificant difference between groups with and without concomitant expression of all three molecules.

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